Pyrimethamine
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- $5 - $1880
- Product name: Pyrimethamine
- CAS: 58-14-0
- MF: C12H13ClN4
- MW: 248.71
- EINECS:200-364-2
- MDL Number:MFCD00057350
- Synonyms:2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine;[2-amino-5-(4-chlorophenyl)-6-ethyl-pyrimidin-4-yl]amine;Pyrimethamine,5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine;Pyrimethamine (200 mg);PyriMethaMine,darapriM;5-(p-chlorophenyl)-6-ethyl-4-pyrimidinediamine ;BW 50-63;bw50-63
51 prices
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Brand
- AHH
- AK Scientific
- Ambeed
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Cayman Chemical
- Chem-Impex
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
- Tocris
- TRC
- Usbiological
Package
- 10mg
- 25mg
- 50mg
- 200mg
- 500mg
- 50
- p4200000
- 0.5g
- 10mM(in 1mL DMSO)
- 100mg
- 250mg
- 1g
- 5g
- 10g
- 25g
- 100g
- 1500g
- ManufacturerAHH
- Product numberMT-22037
- Product descriptionPyrimethamine 98%
- Packaging1500g
- Price$588
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberJ10587
- Product descriptionPyrimethamine
- Packaging100mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberD897
- Product descriptionPyrimethamine
- Packaging5g
- Price$147
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberD897
- Product descriptionPyrimethamine
- Packaging25g
- Price$589
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA195764
- Product descriptionPyrimethamine 98+%
- Packaging100mg
- Price$5
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA195764
- Product descriptionPyrimethamine 98+%
- Packaging250mg
- Price$7
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA195764
- Product descriptionPyrimethamine 98+%
- Packaging1g
- Price$9
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA195764
- Product descriptionPyrimethamine 98+%
- Packaging5g
- Price$11
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA195764
- Product descriptionPyrimethamine 98+%
- Packaging10g
- Price$19
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA195764
- Product descriptionPyrimethamine 98+%
- Packaging25g
- Price$37
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA195764
- Product descriptionPyrimethamine 98+%
- Packaging100g
- Price$103
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4353
- Product descriptionPyrimethamine
- Packaging100mg
- Price$63
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4353
- Product descriptionPyrimethamine
- Packaging10mM(in 1mL DMSO)
- Price$66
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4353
- Product descriptionPyrimethamine
- Packaging500mg
- Price$133
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS016125
- Product descriptionPyrimethamine ≥98%
- Packaging100mg
- Price$5
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS016125
- Product descriptionPyrimethamine ≥98%
- Packaging250mg
- Price$7
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AHH | MT-22037 | Pyrimethamine 98% | 1500g | $588 | 2021-12-16 | Buy |
| AK Scientific | J10587 | Pyrimethamine | 100mg | $95 | 2021-12-16 | Buy |
| AK Scientific | D897 | Pyrimethamine | 5g | $147 | 2021-12-16 | Buy |
| AK Scientific | D897 | Pyrimethamine | 25g | $589 | 2021-12-16 | Buy |
| Ambeed | A195764 | Pyrimethamine 98+% | 100mg | $5 | 2021-12-16 | Buy |
| Ambeed | A195764 | Pyrimethamine 98+% | 250mg | $7 | 2021-12-16 | Buy |
| Ambeed | A195764 | Pyrimethamine 98+% | 1g | $9 | 2021-12-16 | Buy |
| Ambeed | A195764 | Pyrimethamine 98+% | 5g | $11 | 2021-12-16 | Buy |
| Ambeed | A195764 | Pyrimethamine 98+% | 10g | $19 | 2021-12-16 | Buy |
| Ambeed | A195764 | Pyrimethamine 98+% | 25g | $37 | 2021-12-16 | Buy |
| Ambeed | A195764 | Pyrimethamine 98+% | 100g | $103 | 2021-12-16 | Buy |
| ApexBio Technology | A4353 | Pyrimethamine | 100mg | $63 | 2021-12-16 | Buy |
| ApexBio Technology | A4353 | Pyrimethamine | 10mM(in 1mL DMSO) | $66 | 2021-12-16 | Buy |
| ApexBio Technology | A4353 | Pyrimethamine | 500mg | $133 | 2021-12-16 | Buy |
| Arctom | AS016125 | Pyrimethamine ≥98% | 100mg | $5 | 2021-12-16 | Buy |
| Arctom | AS016125 | Pyrimethamine ≥98% | 250mg | $7 | 2021-12-16 | Buy |
Properties
Melting point :233-234°C
Boiling point :393.35°C (rough estimate)
Density :1.2171 (rough estimate)
refractive index :1.6110 (estimate)
storage temp. :Keep in dark place,Inert atmosphere,Room temperature
solubility :Prepare the solution immediately before use. Dissolve 0.25 g in a mixture of 1 volume of methanol R and 3 volumes of methylene chloride R and dilute to 10 mL with the same mixture of solvents. The solution is clear (2.2.1) and not more intensely coloured than reference solution BY6 (2.2.2, Method II).
pka :pKa 7(t=20.0) (Uncertain)
color :White to Off-White
Water Solubility :<0.01 g/100 mL at 21 ºC
λmax :276nm(lit.)
Merck :14,7985
BRN :219864
BCS Class :2 (CLogP), 4 (LogP),3
Stability :Stable, but light sensitive. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference :58-14-0(CAS DataBase Reference)
IARC :3 (Vol. 13, Sup 7) 1987
NIST Chemistry Reference :Pyrimethamine(58-14-0)
EPA Substance Registry System :Pyrimethamine (58-14-0)
Boiling point :393.35°C (rough estimate)
Density :1.2171 (rough estimate)
refractive index :1.6110 (estimate)
storage temp. :Keep in dark place,Inert atmosphere,Room temperature
solubility :Prepare the solution immediately before use. Dissolve 0.25 g in a mixture of 1 volume of methanol R and 3 volumes of methylene chloride R and dilute to 10 mL with the same mixture of solvents. The solution is clear (2.2.1) and not more intensely coloured than reference solution BY6 (2.2.2, Method II).
pka :pKa 7(t=20.0) (Uncertain)
color :White to Off-White
Water Solubility :<0.01 g/100 mL at 21 ºC
λmax :276nm(lit.)
Merck :14,7985
BRN :219864
BCS Class :2 (CLogP), 4 (LogP),3
Stability :Stable, but light sensitive. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference :58-14-0(CAS DataBase Reference)
IARC :3 (Vol. 13, Sup 7) 1987
NIST Chemistry Reference :Pyrimethamine(58-14-0)
EPA Substance Registry System :Pyrimethamine (58-14-0)
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Pyrimethamine is an antiprotozoal agent that is primarily active against P. falciparum, inhibiting the protozoal enzyme dihydrofolate reductase (DHFR). By blocking DHFR activity, pyrimethamine prevents the production of tetrahydrofolic acid, an essential coenzyme involved in DNA and RNA synthesis. In in vivo antimalarial mouse models, pyrimethamine displays a prophylactic effect at an ED50 value of 0.5 mg/kg. Sulphonamides act synergistically with pyrimethamine by arresting production of dihydrofolic acid, resulting in the sequential blockade of the folate pathway of protozoa. Pyrimethamine has also been found to limit the expression of the superoxide dismutase 1 gene, a protein involved in amyotrophic lateral sclerosis.More related product prices
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Suppliers and manufacturers
Frapp's ChemicalNFTZ Co., Ltd.
Capot Chemical Co.,Ltd.
Henan Tianfu Chemical Co.,Ltd.
Hubei Jusheng Technology Co.,Ltd.
Xiamen AmoyChem Co., Ltd
