QS11
|
- $36 - $2200
- Product name: QS11
- CAS: 944328-88-5
- MF: C36H33N5O2
- MW: 567.68
- EINECS:
- MDL Number:MFCD12912439
- Synonyms:QS11;(2S)-2-[2-(Indan-5-yloxy)-9-(1,1'-biphenyl-4-yl)methyl)-9H-purin-6-ylamino]-3-phenyl-propan-1-ol;(betaS)-beta-[[9-([1,1'-Biphenyl]-4-ylmethyl)-2-[(2,3-dihydro-1H-inden-5-yl)oxy]-9H-purin-6-yl]amino]benzenepropanol;QS11 hydrate;Wnt Synergist, QS11;(S)-2-((9-([1,1'-Biphenyl]-4-ylmethyl)-2-((2,3-dihydro-1H-inden-5-yl)oxy)-9H-purin-6-yl)amino);QS 11 (betaS)-beta-[[9-([1,1'-Biphenyl]-4-ylmethyl)-2-[(2,3-dihydro-1H-inden-5-yl)oxy]-9H-purin-6-yl]amino]benzenepropanol;(2S)-2-[2-(Indan-5-yloxy)-9-(1,1′-biphenyl-4-yl)methyl)-9H-purin-6-ylamino]-3-phenyl-propan-1-ol hydrate
45 prices
Selected condition：
Brand
- aablocks
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 1mlx10mM(inDMSO)
- 1mg
- 5mg
- 2mg
- 50
- 10
- 10mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 1g
- Manufactureraablocks
- Product numberAA01DNN4
- Product descriptionQS11 free
- Packaging10mg
- Price$82
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA01DNN4
- Product descriptionQS11 free
- Packaging25mg
- Price$147
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA01DNN4
- Product descriptionQS11 free
- Packaging50mg
- Price$211
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA01DNN4
- Product descriptionQS11 free
- Packaging100mg
- Price$307
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA01DNN4
- Product descriptionQS11 free
- Packaging200mg
- Price$412
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA01DNN4
- Product descriptionQS11 free
- Packaging5mg
- Price$59
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA01DNN4
- Product descriptionQS11 free
- Packaging2mg
- Price$44
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA01DNN4
- Product descriptionQS11 free ≥98%
- Packaging1mg
- Price$36
- Updated2026-05-29
- Buy
- ManufacturerAmbeed
- Product numberA820510
- Product descriptionQS11free 98%
- Packaging5mg
- Price$134
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberBRS0000861
- Product descriptionQS-11 95.00%
- Packaging5MG
- Price$283.8
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0008280
- Product descriptionQS-11 HYDRATE 95.00%
- Packaging5MG
- Price$272.8
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7364
- Product descriptionQS 11
- Packaging25mg
- Price$561
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB7364
- Product descriptionQS 11
- Packaging10mg
- Price$228
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB7364
- Product descriptionQS 11
- Packaging5mg
- Price$167
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB7364
- Product descriptionQS 11
- Packaging50mg
- Price$963
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB7364
- Product descriptionQS 11
- Packaging100mg
- Price$1540
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA01DNN4 | QS11 free | 10mg | $82 | 2026-05-29 | Buy |
| aablocks | AA01DNN4 | QS11 free | 25mg | $147 | 2026-05-29 | Buy |
| aablocks | AA01DNN4 | QS11 free | 50mg | $211 | 2026-05-29 | Buy |
| aablocks | AA01DNN4 | QS11 free | 100mg | $307 | 2026-05-29 | Buy |
| aablocks | AA01DNN4 | QS11 free | 200mg | $412 | 2026-05-29 | Buy |
| aablocks | AA01DNN4 | QS11 free | 5mg | $59 | 2026-05-29 | Buy |
| aablocks | AA01DNN4 | QS11 free | 2mg | $44 | 2026-05-29 | Buy |
| aablocks | AA01DNN4 | QS11 free ≥98% | 1mg | $36 | 2026-05-29 | Buy |
| Ambeed | A820510 | QS11free 98% | 5mg | $134 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | BRS0000861 | QS-11 95.00% | 5MG | $283.8 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008280 | QS-11 HYDRATE 95.00% | 5MG | $272.8 | 2021-12-16 | Buy |
| ApexBio Technology | B7364 | QS 11 | 25mg | $561 | 2026-05-06 | Buy |
| ApexBio Technology | B7364 | QS 11 | 10mg | $228 | 2026-05-06 | Buy |
| ApexBio Technology | B7364 | QS 11 | 5mg | $167 | 2026-05-06 | Buy |
| ApexBio Technology | B7364 | QS 11 | 50mg | $963 | 2026-05-06 | Buy |
| ApexBio Technology | B7364 | QS 11 | 100mg | $1540 | 2026-05-06 | Buy |
Properties
Boiling point :852.2±75.0 °C(Predicted)
Density :1.27
storage temp. :Keep in dark place,Sealed in dry,2-8°C
solubility :Soluble in DMSO
form :Pale amber solid
pka :14.46±0.10(Predicted)
color :White to off-white
InChIKey :DOKZLKDGUQWMSX-HKBQPEDESA-N
SMILES :[n]3(c4nc(nc(c4nc3)N[C@H](CO)Cc7ccccc7)Oc5cc6c(cc5)CCC6)Cc1ccc(cc1)c2ccccc2
Density :1.27
storage temp. :Keep in dark place,Sealed in dry,2-8°C
solubility :Soluble in DMSO
form :Pale amber solid
pka :14.46±0.10(Predicted)
color :White to off-white
InChIKey :DOKZLKDGUQWMSX-HKBQPEDESA-N
SMILES :[n]3(c4nc(nc(c4nc3)N[C@H](CO)Cc7ccccc7)Oc5cc6c(cc5)CCC6)Cc1ccc(cc1)c2ccccc2
Safety Information
| Symbol(GHS): |
|
|||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | |||||||||||||||||||||
| Hazard statements: |
|
|||||||||||||||||||||
| Precautionary statements: |
|
Description
Wnt Synergist, QS11 is a cell-permeable purine compound that binds GTPase activating proteins of ADP-ribosylation factor (ARFGAPs), including AMAP1 (Kd = 364 nM) and ARFGAP1 (Kd = 620 nM) and acts as a broad specificity ARFGAP1 inhibitor. Wnt Synergist, QS11 has also been reported to block the migration of AMAP1-overexpressing MDA-MB-231 cells (86% inhibition at 2.5 μM).Additionally, Wnt Synergist, QS11 has been shown to work synergistically with Wnt-3a to specifically activate the Wnt/β-catenin signaling pathway in vitro. A Super(8X)TOPFlash reporter assay using HEK293 cells revealed increases in basal transcription activity by application of QS11 (2-fold), Wnt-3a (40-fold), and QS11/Wnt-3a (200-fold).
Suppliers and manufacturers
Career Henan Chemica Co
Zhejiang J&C Biological Technology Co.,Limited
TargetMol Chemicals Inc.
Zibo Hangyu Biotechnology Development Co., Ltd
Aladdin Scientific
Soochow Chirally Material Science and Technology Co.,Ltd
BeiJing Hwrk Chemicals Limted
ChemCell Biomedicine Co.,Ltd.
Dalian Meilun Biotech Co., Ltd.
