RAF709
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- $44 - $1800
- Product name: RAF709
- CAS: 1628838-42-5
- MF: C28H29F3N4O4
- MW: 542.55
- EINECS:
- MDL Number:MFCD30534393
- Synonyms:RAF709;CS-2505;RAF-709;RAF 709;Benzamide, N-[2-methyl-5'-(4-morpholinyl)-6'-[(tetrahydro-2H-pyran-4-yl)oxy][3,3'-bipyridin]-5-yl]-3-(trifluoromethyl)-;N-[2-Methyl-5'-(4-morpholinyl)-6'-[(tetrahydro-2H-pyran-4-yl)oxy][3,3'-bipyridin]-5-yl]-3-(trifluoromethyl)benzamide;Inhibitor,inhibit,Raf,Raf kinases,RAF709,RAF-709,RAF 709;N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide;RAF709, 10 mM in DMSO
35 prices
Selected condition：
Brand
- ACHEMBLOCK
- AK Scientific
- Arctom
- Axon Medchem
- Cayman Chemical
- ChemScene
- DC Chemicals
Package
- 1mg
- 10mM*1mLinDMSO(Solution)
- 250mg
- 10mM*1mLinDMSO
- 1g
- 10mM*1mLinDMSO(Solid+Solvent)
- 5mg
- 10mg
- 25MG
- 50mg
- 100MG
- ManufacturerACHEMBLOCK
- Product numberS72373
- Product descriptionRAF-709 98%
- Packaging25MG
- Price$150
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberS72373
- Product descriptionRAF-709 98%
- Packaging25MG
- Price$150
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberS72373
- Product descriptionRAF-709 98%
- Packaging100MG
- Price$270
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberS72373
- Product descriptionRAF-709 98%
- Packaging100MG
- Price$270
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number3613EB
- Product descriptionN-[6-Methyl-5-[5-morpholin-4-yl-6-(oxan-4-yloxy)pyridin-3-yl]pyridin-3-yl]-3-(trifluoromethyl)benzamide
- Packaging10mg
- Price$455
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberHY-100510
- Product descriptionRAF709 99.92%
- Packaging50mg
- Price$513
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-100510
- Product descriptionRAF709 99.92%
- Packaging100mg
- Price$826
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberSLK-S8690
- Product descriptionRAF709 99.86%
- Packaging100mg
- Price$922
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberSLK-S8690
- Product descriptionRAF709 99.86%
- Packaging25mg
- Price$447
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-100510
- Product descriptionRAF709 99.92%
- Packaging25mg
- Price$314
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-100510
- Product descriptionRAF709 99.92%
- Packaging10mg
- Price$157
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-100510
- Product descriptionRAF709 99.92%
- Packaging5mg
- Price$95
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-100510
- Product descriptionRAF709 99.92%
- Packaging10mM*1mLinDMSO(Solid+Solvent)
- Price$107
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-100510
- Product descriptionRAF709 99.92%
- Packaging10mM*1mLinDMSO(Solution)
- Price$113
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberSLK-S8690
- Product descriptionRAF709 99.86%
- Packaging5mg
- Price$140
- Updated2026-05-26
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2817
- Product descriptionRAF709
- Packaging10mg
- Price$132
- Updated2026-05-19
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| ACHEMBLOCK | S72373 | RAF-709 98% | 25MG | $150 | 2026-05-25 | Buy |
| ACHEMBLOCK | S72373 | RAF-709 98% | 25MG | $150 | 2026-05-27 | Buy |
| ACHEMBLOCK | S72373 | RAF-709 98% | 100MG | $270 | 2026-05-25 | Buy |
| ACHEMBLOCK | S72373 | RAF-709 98% | 100MG | $270 | 2026-05-27 | Buy |
| AK Scientific | 3613EB | N-[6-Methyl-5-[5-morpholin-4-yl-6-(oxan-4-yloxy)pyridin-3-yl]pyridin-3-yl]-3-(trifluoromethyl)benzamide | 10mg | $455 | 2021-12-16 | Buy |
| Arctom | HY-100510 | RAF709 99.92% | 50mg | $513 | 2026-05-26 | Buy |
| Arctom | HY-100510 | RAF709 99.92% | 100mg | $826 | 2026-05-26 | Buy |
| Arctom | SLK-S8690 | RAF709 99.86% | 100mg | $922 | 2026-05-26 | Buy |
| Arctom | SLK-S8690 | RAF709 99.86% | 25mg | $447 | 2026-05-26 | Buy |
| Arctom | HY-100510 | RAF709 99.92% | 25mg | $314 | 2026-05-26 | Buy |
| Arctom | HY-100510 | RAF709 99.92% | 10mg | $157 | 2026-05-26 | Buy |
| Arctom | HY-100510 | RAF709 99.92% | 5mg | $95 | 2026-05-26 | Buy |
| Arctom | HY-100510 | RAF709 99.92% | 10mM*1mLinDMSO(Solid+Solvent) | $107 | 2026-05-26 | Buy |
| Arctom | HY-100510 | RAF709 99.92% | 10mM*1mLinDMSO(Solution) | $113 | 2026-05-26 | Buy |
| Arctom | SLK-S8690 | RAF709 99.86% | 5mg | $140 | 2026-05-26 | Buy |
| Axon Medchem | Axon2817 | RAF709 | 10mg | $132 | 2026-05-19 | Buy |
Properties
Boiling point :622.7±55.0 °C(Predicted)
Density :1.321±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:100.0(Max Conc. mg/mL);184.31(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.61(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);55.29(Max Conc. mM)
Ethanol:100.0(Max Conc. mg/mL);184.31(Max Conc. mM) form :A crystalline solid
pka :11.87±0.70(Predicted)
color :White to off-white
Density :1.321±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:100.0(Max Conc. mg/mL);184.31(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.61(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);55.29(Max Conc. mM)
Ethanol:100.0(Max Conc. mg/mL);184.31(Max Conc. mM) form :A crystalline solid
pka :11.87±0.70(Predicted)
color :White to off-white
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
RAF709 is a potent inhibitor of B-RAF and C-RAF (IC50s = 0.4 and 0.5 nM, respectively). It is selective for RAF kinases exhibiting >99% inhibition of only B-RAF, B-RAFV600E, and C-RAF in a panel of 456 kinases. However, DDR1, DDR2, FRK, and PDGFRβ are also inhibited by >80% at a concentration of 1 μM. RAF709 inhibits phosphorylation of MEK and ERK (EC50s = 0.02 and 0.1 μM, respectively) with minimal paradoxical activation, stabilizes BRAF-CRAF dimers (EC50 = 0.8 μM), and reduces proliferation of Calu-6 RAS mutant cells (EC50 = 0.95 μM). In a Calu-6 mouse non-small cell lung cancer (NSCLC) xenograft model, RAF709 (10-200 mg/kg) reduces ERK phosphorylation and decreases tumor volume in a dose-dependent manner without affecting total body weight.Related product price
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