Roflumilast
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- $5 - $1789
- Product name: Roflumilast
- CAS: 162401-32-3
- MF: C17H14Cl2F2N2O3
- MW: 403.21
- EINECS:685-382-2
- MDL Number:MFCD00938270
- Synonyms:ROFLUMILAST;3-(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide;B 9302-107;BY 217;BYK 20869;Daxas;Roflumilast / 3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide;3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide
81 prices
Selected condition：
Brand
- AccelPharmtech
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chemcia Scientific
- Chem-Impex
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
- Tocris
- TRC
- Usbiological
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- 10mM(in 1mL DMSO)
- 50
- 10
- 5g
- 10mM*1mLinDMSO
- 10G
- 25G
- 100G
- 250G
- 10mM(in1mLDMSO)
- ManufacturerAccelPharmtech
- Product numberAT7298
- Product descriptionRoflumilast 99.00%
- Packaging10G
- Price$210
- Updated2026-05-21
- Buy
- ManufacturerAccelPharmtech
- Product numberAT7298
- Product descriptionRoflumilast 99.00%
- Packaging25G
- Price$320
- Updated2026-05-21
- Buy
- ManufacturerAccelPharmtech
- Product numberAT7298
- Product descriptionRoflumilast 99.00%
- Packaging100G
- Price$840
- Updated2026-05-21
- Buy
- ManufacturerAccelPharmtech
- Product numberAT7298
- Product descriptionRoflumilast 99.00%
- Packaging250G
- Price$1690
- Updated2026-05-21
- Buy
- ManufacturerAK Scientific
- Product numberJ11524
- Product descriptionRoflumilast
- Packaging25mg
- Price$49
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberJ11524
- Product descriptionRoflumilast
- Packaging100mg
- Price$98
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberJ90119
- Product descriptionRoflumilast
- Packaging5g
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA168666
- Product description3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide 99+%
- Packaging5g
- Price$133
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA168666
- Product description3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide 99+%
- Packaging1g
- Price$34
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA168666
- Product description3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide 99+%
- Packaging5mg
- Price$5
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA168666
- Product description3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide 99+%
- Packaging10mg
- Price$6
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA168666
- Product description3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide 99+%
- Packaging50mg
- Price$8
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA168666
- Product description3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide 99+%
- Packaging250mg
- Price$13
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA168666
- Product description3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide 99+%
- Packaging25g
- Price$542
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA168666
- Product description3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide 99+%
- Packaging100g
- Price$1789
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0004090
- Product descriptionROFLUMILAST 95.00%
- Packaging1G
- Price$210
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AccelPharmtech | AT7298 | Roflumilast 99.00% | 10G | $210 | 2026-05-21 | Buy |
| AccelPharmtech | AT7298 | Roflumilast 99.00% | 25G | $320 | 2026-05-21 | Buy |
| AccelPharmtech | AT7298 | Roflumilast 99.00% | 100G | $840 | 2026-05-21 | Buy |
| AccelPharmtech | AT7298 | Roflumilast 99.00% | 250G | $1690 | 2026-05-21 | Buy |
| AK Scientific | J11524 | Roflumilast | 25mg | $49 | 2021-12-16 | Buy |
| AK Scientific | J11524 | Roflumilast | 100mg | $98 | 2021-12-16 | Buy |
| AK Scientific | J90119 | Roflumilast | 5g | $120 | 2021-12-16 | Buy |
| Ambeed | A168666 | 3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide 99+% | 5g | $133 | 2021-12-16 | Buy |
| Ambeed | A168666 | 3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide 99+% | 1g | $34 | 2021-12-16 | Buy |
| Ambeed | A168666 | 3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide 99+% | 5mg | $5 | 2021-12-16 | Buy |
| Ambeed | A168666 | 3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide 99+% | 10mg | $6 | 2021-12-16 | Buy |
| Ambeed | A168666 | 3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide 99+% | 50mg | $8 | 2021-12-16 | Buy |
| Ambeed | A168666 | 3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide 99+% | 250mg | $13 | 2021-12-16 | Buy |
| Ambeed | A168666 | 3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide 99+% | 25g | $542 | 2021-12-16 | Buy |
| Ambeed | A168666 | 3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide 99+% | 100g | $1789 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0004090 | ROFLUMILAST 95.00% | 1G | $210 | 2021-12-16 | Buy |
Properties
Melting point :158°C
Boiling point :430.6±45.0 °C(Predicted)
Density :1.471±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble20mg/mL, clear
pka :9.89±0.70(Predicted)
form :powder
color :white to beige
Merck :14,8249
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI :InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24)
InChIKey :MNDBXUUTURYVHR-UHFFFAOYSA-N
SMILES :C(NC1C(Cl)=CN=CC=1Cl)(=O)C1=CC=C(OC(F)F)C(OCC2CC2)=C1
CAS DataBase Reference :162401-32-3(CAS DataBase Reference)
Boiling point :430.6±45.0 °C(Predicted)
Density :1.471±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble20mg/mL, clear
pka :9.89±0.70(Predicted)
form :powder
color :white to beige
Merck :14,8249
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI :InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24)
InChIKey :MNDBXUUTURYVHR-UHFFFAOYSA-N
SMILES :C(NC1C(Cl)=CN=CC=1Cl)(=O)C1=CC=C(OC(F)F)C(OCC2CC2)=C1
CAS DataBase Reference :162401-32-3(CAS DataBase Reference)
Safety Information
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Description
Type 4 cyclic nucleotide phosphodiesterase (PDE4) isoforms selectively inactivate the second messenger cAMP by hydrolyzing the phosphodiester bond, producing AMP. Roflumilast is a potent, cell-permeable inhibitor of PDE4 (IC50 = < 1 nM for both human PDE4B and PDE4D). It is selective for PDE4, with IC50 values against other PDE forms being greater than 10 μM. Roflumilast demonstrates good bioavailability and has applications in respiratory diseases, including asthma and chronic obstructive pulmonary disease.More related product prices
2-Chloro-5-chloromethylpyridine Fleroxacin Clopyralid Benzamide p-Aminobenzamide Ezetimibe 162401-62-9 benzaMide, N-(3,5-dichloro-4-pyridinyl)-4-(difluoroMethoxy)-3-hydroxy- 22889-78-7 RofluMilast related substance RofluMilast related substance RofluMilast N-Oxide N-(3,5-Dichloro-4-pyridinyl)-3,4-bis(difluoroMethoxy)benzaMide BenzaMide, 3,4-bis(cyclopropylMethoxy)-N-(3,5-dichloro-4-pyridinyl)- RofluMilast related substance N-(3-Chloropyridin-4-yl)-3-(cyclopropylMethoxy)-4-(difluoroMethoxy)benzaMideRelated product price
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$29-1880
Suppliers and manufacturers
Henan Tianfu Chemical Co.,Ltd.
Nanjing ChemLin Chemical Industry Co., Ltd.
Shanghai Yingrui Biopharma Co., Ltd.
ATK CHEMICAL COMPANY LIMITED
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