Rucaparib
|
- $5 - $1350
- Product name: Rucaparib
- CAS: 283173-50-2
- MF: C19H18FN3O
- MW: 323.36
- EINECS:814-445-0
- MDL Number:MFCD11977252
- Synonyms:8-FLUOR-2-{4-[(METHYLAMINO)METHYL]FENYL}-1,3,4,5-TETRAHYDRO-6HAZEPINO[5,4,3-CD]INDOOL-6-ON;8-fluoro-2-(4-((methylamino)methyl)phenyl)-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one;6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one, 8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-;8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one;8-Fluoro-2-[4-[(methylamino)methyl]phenyl]-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one;Rucaparib;rucaparib (PARP inhibitor) ORPHAN DRUG;PF-01367388
79 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Ambeed
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- TCI Chemical
- TRC
Package
- 2mg
- 0.05g
- 0.1g
- 200mg
- 0.25g
- 250.00mg
- 500mg
- 0.5g
- 1.00g
- 5.00g
- 10mM(in1mLDMSO)
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- 5g
- 10g
- Manufactureraablocks
- Product numberAA0037CS
- Product description6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one,8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]- 97%
- Packaging1mg
- Price$5
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0037CS
- Product description6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one,8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]- 97%
- Packaging5mg
- Price$6
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0037CS
- Product description6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one,8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]- 97%
- Packaging10mg
- Price$8
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0037CS
- Product description6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one,8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]- 98%
- Packaging25mg
- Price$19
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0037CS
- Product description6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one,8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]- ≥98%
- Packaging50mg
- Price$19
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0037CS
- Product description6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one,8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]- 97%
- Packaging100mg
- Price$25
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0037CS
- Product description6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one,8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]- 98%
- Packaging250mg
- Price$44
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0037CS
- Product description6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one,8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]- 98%
- Packaging1g
- Price$115
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0037CS
- Product description6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one,8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]- 98%
- Packaging5g
- Price$507
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0037CS
- Product description6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one,8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]- 98%
- Packaging10g
- Price$840
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15391
- Product descriptionRucaparib 98%
- Packaging5G
- Price$460
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15391
- Product descriptionRucaparib 98%
- Packaging1G
- Price$130
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15391
- Product descriptionRucaparib 98%
- Packaging100MG
- Price$35
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberX7541
- Product descriptionRucaparib
- Packaging10mg
- Price$84
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7541
- Product descriptionRucaparib
- Packaging1g
- Price$288
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA115210
- Product descriptionRucaparib 98+%
- Packaging1g
- Price$145
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA0037CS | 6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one,8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]- 97% | 1mg | $5 | 2026-05-28 | Buy |
| aablocks | AA0037CS | 6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one,8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]- 97% | 5mg | $6 | 2026-05-28 | Buy |
| aablocks | AA0037CS | 6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one,8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]- 97% | 10mg | $8 | 2026-05-28 | Buy |
| aablocks | AA0037CS | 6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one,8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]- 98% | 25mg | $19 | 2026-05-28 | Buy |
| aablocks | AA0037CS | 6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one,8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]- ≥98% | 50mg | $19 | 2026-05-28 | Buy |
| aablocks | AA0037CS | 6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one,8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]- 97% | 100mg | $25 | 2026-05-28 | Buy |
| aablocks | AA0037CS | 6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one,8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]- 98% | 250mg | $44 | 2026-05-28 | Buy |
| aablocks | AA0037CS | 6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one,8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]- 98% | 1g | $115 | 2026-05-28 | Buy |
| aablocks | AA0037CS | 6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one,8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]- 98% | 5g | $507 | 2026-05-28 | Buy |
| aablocks | AA0037CS | 6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one,8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]- 98% | 10g | $840 | 2026-05-28 | Buy |
| ACHEMBLOCK | M15391 | Rucaparib 98% | 5G | $460 | 2026-05-27 | Buy |
| ACHEMBLOCK | M15391 | Rucaparib 98% | 1G | $130 | 2026-05-27 | Buy |
| ACHEMBLOCK | M15391 | Rucaparib 98% | 100MG | $35 | 2026-05-27 | Buy |
| AK Scientific | X7541 | Rucaparib | 10mg | $84 | 2021-12-16 | Buy |
| AK Scientific | X7541 | Rucaparib | 1g | $288 | 2021-12-16 | Buy |
| Ambeed | A115210 | Rucaparib 98+% | 1g | $145 | 2021-12-16 | Buy |
Properties
Melting point :187 - 189°C
Boiling point :625.2±55.0 °C(Predicted)
Density :1.281
storage temp. :2-8°C(protect from light)
solubility :DMSO (Slightly), Methanol (Slightly)
form :Yellow solid.
pka :14.10±0.20(Predicted)
color :Pale Yellow to Yellow
InChI :InChI=1S/C19H18FN3O/c1-21-10-11-2-4-12(5-3-11)18-14-6-7-22-19(24)15-8-13(20)9-16(23-18)17(14)15/h2-5,8-9,21,23H,6-7,10H2,1H3,(H,22,24)
InChIKey :HMABYWSNWIZPAG-UHFFFAOYSA-N
SMILES :N1C(=O)C2=CC(F)=CC3NC(C4=CC=C(CNC)C=C4)=C(C2=3)CC1
Boiling point :625.2±55.0 °C(Predicted)
Density :1.281
storage temp. :2-8°C(protect from light)
solubility :DMSO (Slightly), Methanol (Slightly)
form :Yellow solid.
pka :14.10±0.20(Predicted)
color :Pale Yellow to Yellow
InChI :InChI=1S/C19H18FN3O/c1-21-10-11-2-4-12(5-3-11)18-14-6-7-22-19(24)15-8-13(20)9-16(23-18)17(14)15/h2-5,8-9,21,23H,6-7,10H2,1H3,(H,22,24)
InChIKey :HMABYWSNWIZPAG-UHFFFAOYSA-N
SMILES :N1C(=O)C2=CC(F)=CC3NC(C4=CC=C(CNC)C=C4)=C(C2=3)CC1
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Poly(ADP-ribose) polymerases (PARPs) are activated by DNA single- and double-strand breaks and promote repair of DNA damage through the relaxation of chromatin and recruitment of other repair proteins. Inhibition of PARP activity has been linked to synthetic lethality in cells with mutations in BRCA1 or BRCA2 and is used as a therapeutic strategy to selectively target cancers. Rucaparib is a potent, cell-permeable inhibitor of PARP1 (Ki = <5 nM) that is used in clinical therapy to sensitize cancer cells to chemotherapy. Rucaparib inactivates PARP activity in cells with homologous recombination DNA repair pathway mutations at LC50 values ranging from 1.3-5.5 μM. At 25 mg/kg, rucaparib arrests tumor growth in mice bearing epigenetically silenced BRCA1 UACC3199 xenograft tumors. It has been shown to increase efficacy of temozolomide in medulloblastoma cells and xenografts.Related product price
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Suppliers and manufacturers
Shanghai Boyle Chemical Co., Ltd.
Chembest Research Laboratories Limited
Shanghai Feibo Chemical Technology Co., Ltd
Shanghai Cuisen Pharmaceutical Technology Co., Ltd.
T&W GROUP
Shanghai Topbiochem Technology Co., Ltd
NCE Biomedical Co.,Ltd.
Nanjing Sunlida Biological Technology Co., Ltd.
TargetMol Chemicals Inc.
ShangHai Zexin Chemical Technology Co., Ltd.