SAG
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- $29 - $5780
- Product name: SAG
- CAS: 912545-86-9
- MF: C28H28ClN3OS
- MW: 490.06
- EINECS:
- MDL Number:MFCD22581513
- Synonyms:3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]- benzo[b]thiophene-2-carboxamide;SAG;3-Chloro-N-[trans-4-(MethylaMino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]Methyl]-;SAG (cyclopamine antagonist);SAG (Smo agonist);3-chloro-N-((1r,4r)-4-(methylamino)cyclohexyl)-N-(3-(pyridin-4-yl)benzyl)benzo[b]thiophene-2-carboxamide;Smoothened Agonist (SAG) HCl;SAG.HCI
92 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- ApexBio Technology
- Apolloscientific
- Arctom
- AvaChem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Thermo Scientific Chemicals
- Tocris
- TRC
- Usbiological
Package
- 50ug
- 100ug
- 500μg
- 250mg
- 500mg
- 1000mg
- 2000mg
- 1mlx10mM(inDMSO)
- 1g
- 1
- 96Tests
- 10mM*1mLinDMSO
- 10mM(in 1mL DMSO)
- 1mg
- 10mM*1mLinDMSO(Solution)
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 200mg
- 100MG
- 10mM(1mLinDMSO)
- Manufactureraablocks
- Product numberAA003A7G
- Product description3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide ≥98%
- Packaging1mg
- Price$29
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003A7G
- Product description3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide
- Packaging5mg
- Price$87
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003A7G
- Product description3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide
- Packaging10mg
- Price$119
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003A7G
- Product description3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide
- Packaging25mg
- Price$217
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003A7G
- Product description3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide
- Packaging50mg
- Price$292
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15335
- Product descriptionSAG 98%
- Packaging25MG
- Price$295
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15335
- Product descriptionSAG 98%
- Packaging100MG
- Price$600
- Updated2026-05-27
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3506-M025
- Product descriptionSAG ≥98%(NMR)
- Packaging25mg
- Price$250
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3506-M001
- Product descriptionSAG ≥98%(NMR)
- Packaging1mg
- Price$50
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3506-M005
- Product descriptionSAG ≥98%(NMR)
- Packaging5mg
- Price$110
- Updated2026-05-06
- Buy
- ManufacturerAK Scientific
- Product number4020AH
- Product description3-Chloro-N-((1R,4R)-4-(methylamino)cyclohexyl)-N-(3-(pyridin-4-yl)benzyl)benzo[b]thiophene-2-carboxamide
- Packaging10mg
- Price$245
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA880155
- Product description3-Chloro-N-(trans-4-(methylamino)cyclohexyl)-N-(3-(pyridin-4-yl)benzyl)benzo[b]thiophene-2-carboxamide 98+%
- Packaging1mg
- Price$64
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5837
- Product descriptionSAG
- Packaging2mg
- Price$85
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5837
- Product descriptionSAG
- Packaging5mg
- Price$175
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5837
- Product descriptionSAG
- Packaging10mM(in 1mL DMSO)
- Price$270
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5837
- Product descriptionSAG
- Packaging25mg
- Price$525
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA003A7G | 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide ≥98% | 1mg | $29 | 2026-05-28 | Buy |
| aablocks | AA003A7G | 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide | 5mg | $87 | 2026-05-28 | Buy |
| aablocks | AA003A7G | 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide | 10mg | $119 | 2026-05-28 | Buy |
| aablocks | AA003A7G | 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide | 25mg | $217 | 2026-05-28 | Buy |
| aablocks | AA003A7G | 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide | 50mg | $292 | 2026-05-28 | Buy |
| ACHEMBLOCK | M15335 | SAG 98% | 25MG | $295 | 2026-05-27 | Buy |
| ACHEMBLOCK | M15335 | SAG 98% | 100MG | $600 | 2026-05-27 | Buy |
| Adipogen Life Sciences | AG-CR1-3506-M025 | SAG ≥98%(NMR) | 25mg | $250 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-CR1-3506-M001 | SAG ≥98%(NMR) | 1mg | $50 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-CR1-3506-M005 | SAG ≥98%(NMR) | 5mg | $110 | 2026-05-06 | Buy |
| AK Scientific | 4020AH | 3-Chloro-N-((1R,4R)-4-(methylamino)cyclohexyl)-N-(3-(pyridin-4-yl)benzyl)benzo[b]thiophene-2-carboxamide | 10mg | $245 | 2021-12-16 | Buy |
| Ambeed | A880155 | 3-Chloro-N-(trans-4-(methylamino)cyclohexyl)-N-(3-(pyridin-4-yl)benzyl)benzo[b]thiophene-2-carboxamide 98+% | 1mg | $64 | 2021-12-16 | Buy |
| ApexBio Technology | B5837 | SAG | 2mg | $85 | 2021-12-16 | Buy |
| ApexBio Technology | B5837 | SAG | 5mg | $175 | 2021-12-16 | Buy |
| ApexBio Technology | B5837 | SAG | 10mM(in 1mL DMSO) | $270 | 2021-12-16 | Buy |
| ApexBio Technology | B5837 | SAG | 25mg | $525 | 2021-12-16 | Buy |
Properties
Melting point :109-111 °C
Boiling point :688.6±55.0 °C(Predicted)
Density :1.30±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :Soluble in DMSO (up to 20 mg/ml), in DMF (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml).
form :lyophilized solid
pka :10+-.0.40(Predicted)
color :white to beige
Water Solubility :H2O: 20mg/mL, clear
Sensitive :Light Sensitive
Stability :Light Sensitive
InChIKey :VFSUUTYAEQOIMW-YHBQERECSA-N
SMILES :O=C(C1=C(Cl)C2=C(C=CC=C2)S1)N([C@@]3([H])CC[C@@](NC)([H])CC3)CC4=CC(C5=CC=NC=C5)=CC=C4
Boiling point :688.6±55.0 °C(Predicted)
Density :1.30±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :Soluble in DMSO (up to 20 mg/ml), in DMF (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml).
form :lyophilized solid
pka :10+-.0.40(Predicted)
color :white to beige
Water Solubility :H2O: 20mg/mL, clear
Sensitive :Light Sensitive
Stability :Light Sensitive
InChIKey :VFSUUTYAEQOIMW-YHBQERECSA-N
SMILES :O=C(C1=C(Cl)C2=C(C=CC=C2)S1)N([C@@]3([H])CC[C@@](NC)([H])CC3)CC4=CC(C5=CC=NC=C5)=CC=C4
Safety Information
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| Signal word: | Danger | |||||||||||||||||||||
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Description
Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. Smoothened agonist (SAG) is a chlorobenzothiophene-containing compound which acts as a SMO agonist (EC50 = 3 nM) but inhibits hedgehog signaling at high concentrations (>1 μM). It directly binds to SMO and can block SMO inhibition by cyclopamine. Binding of SAG alters the conformation of SMO, leading to its accumulation in cilia and activation of gene transcription. At 15-240 nM, SAG prevents the neurotoxic effects of glucocorticoids without interfering with the beneficial effects of glucocorticoids on lung maturation. At higher concentrations (0.4 mM), SAG improves the conversion of human induced pluripotent stem cells to the neural lineage.Related product price
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Suppliers and manufacturers
Shanghai Boyle Chemical Co., Ltd.
J & K SCIENTIFIC LTD.
Chembest Research Laboratories Limited
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Chemsky（shanghai）International Co.,Ltd.
Dalian Meilun Biotech Co., Ltd.
Haoyuan Chemexpress Co., Ltd.
ShangHai KenEn Chemical Technology Co., Ltd.
AdooQ Bioscience CHINA
Sigma-Aldrich