SAR405838 (MI-773)
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- $44 - $3200
- Product name: SAR405838 (MI-773)
- CAS: 1303607-60-4
- MF: C29H34Cl2FN3O3
- MW: 562.5
- EINECS:-0
- MDL Number:MFCD28976052
- Synonyms:SAR405838 (MI-773);(2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-N-(trans-4-hydroxycyclohexyl)-2-oxo-spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide;MI-773 (SAR405838);SAR405838;SAR405838, MI-77301;MI 77301;SAR405838;SAR-405838;SAR 405838;MI-77301 (SAR405838)
21 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Axon Medchem
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- TRC
Package
- 500μg
- 1mg
- 5MG
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- 10mM(in 1mL DMSO)
- ManufacturerAK Scientific
- Product number3463DL
- Product descriptionMI-773(Sar405838)
- Packaging50mg
- Price$1113
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0004678
- Product description(2'S,3R,4'S,5'R)-6-CHLORO-4'-(3-CHLORO-2-FLUOROPHENYL)-2'-(2,2-DIMETHYLPROPYL)-1,2-DIHYDRO-N-(TRANS-4-HYDROXYCYCLOHEXYL)-2-OXO-SPIRO[3H-INDOLE-3,3'-PYRROLIDINE]-5'-CARBOXAMIDE 95.00%
- Packaging5MG
- Price$502.78
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4984
- Product descriptionMI-77301(SAR405838)
- Packaging5mg
- Price$138
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4984
- Product descriptionMI-77301(SAR405838)
- Packaging10mM(in 1mL DMSO)
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4984
- Product descriptionMI-77301(SAR405838)
- Packaging25mg
- Price$558
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2741
- Product descriptionSAR405838-MI-77301 98%
- Packaging5mg
- Price$137.5
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC76168
- Product descriptionSAR 405838
- Packaging10mg
- Price$225
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC76168
- Product descriptionSAR 405838
- Packaging50mg
- Price$787.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17473
- Product descriptionMI-77301 ≥95%
- Packaging500μg
- Price$44
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17473
- Product descriptionMI-77301 ≥95%
- Packaging1mg
- Price$74
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17473
- Product descriptionMI-77301 ≥95%
- Packaging5mg
- Price$235
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17473
- Product descriptionMI-77301 ≥95%
- Packaging10mg
- Price$426
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-5003
- Product descriptionSAR405838 95.14%
- Packaging5mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-5003
- Product descriptionSAR405838 95.14%
- Packaging10mg
- Price$252
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-5003
- Product descriptionSAR405838 95.14%
- Packaging50mg
- Price$972
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-5003
- Product descriptionSAR405838 95.14%
- Packaging100mg
- Price$1560
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 3463DL | MI-773(Sar405838) | 50mg | $1113 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0004678 | (2'S,3R,4'S,5'R)-6-CHLORO-4'-(3-CHLORO-2-FLUOROPHENYL)-2'-(2,2-DIMETHYLPROPYL)-1,2-DIHYDRO-N-(TRANS-4-HYDROXYCYCLOHEXYL)-2-OXO-SPIRO[3H-INDOLE-3,3'-PYRROLIDINE]-5'-CARBOXAMIDE 95.00% | 5MG | $502.78 | 2021-12-16 | Buy |
| ApexBio Technology | B4984 | MI-77301(SAR405838) | 5mg | $138 | 2021-12-16 | Buy |
| ApexBio Technology | B4984 | MI-77301(SAR405838) | 10mM(in 1mL DMSO) | $250 | 2021-12-16 | Buy |
| ApexBio Technology | B4984 | MI-77301(SAR405838) | 25mg | $558 | 2021-12-16 | Buy |
| Axon Medchem | Axon2741 | SAR405838-MI-77301 98% | 5mg | $137.5 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC76168 | SAR 405838 | 10mg | $225 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC76168 | SAR 405838 | 50mg | $787.5 | 2021-12-16 | Buy |
| Cayman Chemical | 17473 | MI-77301 ≥95% | 500μg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 17473 | MI-77301 ≥95% | 1mg | $74 | 2024-03-01 | Buy |
| Cayman Chemical | 17473 | MI-77301 ≥95% | 5mg | $235 | 2024-03-01 | Buy |
| Cayman Chemical | 17473 | MI-77301 ≥95% | 10mg | $426 | 2024-03-01 | Buy |
| ChemScene | CS-5003 | SAR405838 95.14% | 5mg | $150 | 2021-12-16 | Buy |
| ChemScene | CS-5003 | SAR405838 95.14% | 10mg | $252 | 2021-12-16 | Buy |
| ChemScene | CS-5003 | SAR405838 95.14% | 50mg | $972 | 2021-12-16 | Buy |
| ChemScene | CS-5003 | SAR405838 95.14% | 100mg | $1560 | 2021-12-16 | Buy |
Properties
Boiling point :732.1±60.0 °C(Predicted)
Density :1.36±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥17.2 mg/mL in DMSO
form :Powder
pka :12.03±0.70(Predicted)
Density :1.36±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥17.2 mg/mL in DMSO
form :Powder
pka :12.03±0.70(Predicted)
Safety Information
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Description
The protein p53, often called the ‘guardian of the genome,’ is a transcription factor that is activated in response to cellular stress (low oxygen levels, heat shock, DNA damage, etc.) and acts to prevent further proliferation of the stressed cell by promoting cell cycle arrest or apoptosis. Its role as a tumor suppressor is evident by the observation that approximately 50% of human tumors have mutated or non-functional p53. Mdm2, a key negative regulator of p53, which is over-expressed in many human tumors, functions by binding to and targeting p53 for proteasomal degradation. MI-77301 binds to MDM2 with a Ki value of 0.88 nM and blocks the MDM2-p53 interaction. It activates wild-type p53 in vitro and in xenograft tumor tissue of leukemia and solid tumors, leading to p53-dependent cell cycle arrest and/or apoptosis. In an SJSA-1 xenograft model of osteosarcoma, a single dose of 200 mg/kg MI-77301 induces complete tumor regression in mice by upregulating the pro-apoptotic protein PUMA.More related product prices
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