SIS3
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- $29 - $3791
- Product name: SIS3
- CAS: 521984-48-5
- MF: C28H27N3O3HCl
- MW: 0
- EINECS:
- MDL Number:MFCD09265258
- Synonyms:SIS3;(2E)-1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-propenone hydrochloride;2-Propen-1-one,1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-,hydrochloride (1:1), (2E)-;SIS3 hydrochloride;SIS3 HCl;1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-oxo-2-propenyl]-isoquinoline Monohydrochloride;Caneritinib(CI-1033);SIS 3 HCL;SIS-3 HCL
54 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Biosynth
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- TCI Chemical
- Tocris
- TRC
- Usbiological
Package
- 10
- 10mM(1mLinDMSO)
- 2.5mg
- 1mg
- 2mg
- 50
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1G
- Manufactureraablocks
- Product numberAA00DB8G
- Product descriptionSIS3 99%
- Packaging1mg
- Price$29
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00DB8G
- Product descriptionSIS3 99%
- Packaging2mg
- Price$42
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00DB8G
- Product descriptionSIS3 99%
- Packaging5mg
- Price$81
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00DB8G
- Product descriptionSIS3 99%
- Packaging10mg
- Price$125
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00DB8G
- Product descriptionSIS3 99
- Packaging25mg
- Price$311
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00DB8G
- Product descriptionSIS3 99
- Packaging50mg
- Price$451
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00DB8G
- Product descriptionSIS3 99
- Packaging100mg
- Price$635
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberP51703
- Product descriptionSIS3 hydrochloride 98%
- Packaging1G
- Price$790
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberP51703
- Product descriptionSIS3 hydrochloride 98%
- Packaging100MG
- Price$250
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberP51703
- Product descriptionSIS3 hydrochloride 98%
- Packaging25MG
- Price$95
- Updated2026-05-27
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0004710
- Product description1-(3,4-DIHYDRO-6,7-DIMETHOXY-2(1H)-ISOQUINOLINYL)-3-(1-METHYL-2-PHENYL-1H-PYRROLO[2,3-B]PYRIDIN-3-YL)-, HYDROCHLORIDE-2-PROPEN-1-ONE 95.00%
- Packaging5MG
- Price$505.04
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6096
- Product descriptionSIS3
- Packaging25mg
- Price$313
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6096
- Product descriptionSIS3
- Packaging25mg
- Price$313
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB6096
- Product descriptionSIS3
- Packaging5mg
- Price$103
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6096
- Product descriptionSIS3
- Packaging5mg
- Price$103
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB6096
- Product descriptionSIS3
- Packaging2mg
- Price$68
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00DB8G | SIS3 99% | 1mg | $29 | 2026-05-28 | Buy |
| aablocks | AA00DB8G | SIS3 99% | 2mg | $42 | 2026-05-28 | Buy |
| aablocks | AA00DB8G | SIS3 99% | 5mg | $81 | 2026-05-28 | Buy |
| aablocks | AA00DB8G | SIS3 99% | 10mg | $125 | 2026-05-28 | Buy |
| aablocks | AA00DB8G | SIS3 99 | 25mg | $311 | 2026-05-28 | Buy |
| aablocks | AA00DB8G | SIS3 99 | 50mg | $451 | 2026-05-28 | Buy |
| aablocks | AA00DB8G | SIS3 99 | 100mg | $635 | 2026-05-28 | Buy |
| ACHEMBLOCK | P51703 | SIS3 hydrochloride 98% | 1G | $790 | 2026-05-27 | Buy |
| ACHEMBLOCK | P51703 | SIS3 hydrochloride 98% | 100MG | $250 | 2026-05-27 | Buy |
| ACHEMBLOCK | P51703 | SIS3 hydrochloride 98% | 25MG | $95 | 2026-05-27 | Buy |
| American Custom Chemicals Corporation | INB0004710 | 1-(3,4-DIHYDRO-6,7-DIMETHOXY-2(1H)-ISOQUINOLINYL)-3-(1-METHYL-2-PHENYL-1H-PYRROLO[2,3-B]PYRIDIN-3-YL)-, HYDROCHLORIDE-2-PROPEN-1-ONE 95.00% | 5MG | $505.04 | 2021-12-16 | Buy |
| ApexBio Technology | B6096 | SIS3 | 25mg | $313 | 2021-12-16 | Buy |
| ApexBio Technology | B6096 | SIS3 | 25mg | $313 | 2026-05-06 | Buy |
| ApexBio Technology | B6096 | SIS3 | 5mg | $103 | 2021-12-16 | Buy |
| ApexBio Technology | B6096 | SIS3 | 5mg | $103 | 2026-05-06 | Buy |
| ApexBio Technology | B6096 | SIS3 | 2mg | $68 | 2021-12-16 | Buy |
Properties
Melting point :>161°C (dec.)
storage temp. :2-8°C
solubility :H2O: <2mg/mL
form :powder
color :yellow
Water Solubility :H2O: <2mg/mL
DMSO: >20mg/mL InChIKey :CDKIEBFIMCSCBB-CALJPSDSSA-N
SMILES :N1(C)C2N=CC=CC=2C(/C=C/C(=O)N2CCC3C=C(OC)C(OC)=CC=3C2)=C1C1C=CC=CC=1.Cl
storage temp. :2-8°C
solubility :H2O: <2mg/mL
form :powder
color :yellow
Water Solubility :H2O: <2mg/mL
DMSO: >20mg/mL InChIKey :CDKIEBFIMCSCBB-CALJPSDSSA-N
SMILES :N1(C)C2N=CC=CC=2C(/C=C/C(=O)N2CCC3C=C(OC)C(OC)=CC=3C2)=C1C1C=CC=CC=1.Cl
Safety Information
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Description
SIS3 hydrochloride is a specific inhibitor of Smad3 phosphorylation via inhibiting the effects of TGF-β1. Studies conducted on scleroderma fibroblasts indicate that SIS3 hydrochloride suppresses type I collagen up-regulation. In addition, SIS3 hydrochloride inhibits Smad-responsive p3TP promoter constructs activation. These studies suggest that SIS3 hydrochloride reduces DNA binding of Smad3 and that pretreatment with SIS3 hydrochloride decreases DNA binding by 50%. SIS3 hydrochloride also interferes with the interaction between contransfected Smad3 and Smad4. Furthermore, SIS3 hydrochloride reestablishes myofibroblast differentiation of scleroderma fibroblasts via reducing expression of α-SMA in these fibroblasts.More related product prices
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