SL 327
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- $12 - $1677
- Product name: SL 327
- CAS: 305350-87-2
- MF: C16H12F3N3S
- MW: 335.35
- EINECS:
- MDL Number:MFCD06411432
- Synonyms:ALPHA-[AMINO[(4-AMINOPHENYL)THIO]METHYLENE]-2-(TRIFLUOROMETHYL)BENZENEACETONITRILE;ALPHA-[AMINO-(4-AMINOPHENYLTHIO)METHYLENE)-2-(TRIFLUOROMETHYL)PHENYLACETONITRILE;SL 327;Z-EPSILON-T E-ALPHA-(AMINO-((4-AMINOPHENYL)THIO)METHYLENE)-2-(TRIFLUOROMETHYL)BENZENEACETONITRILE;Z-AND E-ALPHA-(AMINO-((4-AMINOPHENYL)THIO)METHYLENE)-2-(TRIFLUOROMETHYL)BENZENEACETONITRILE;a-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile;α-[amino-(4-aminophenylthio)methylene)-2-(trifluoromethyl)phenylacetonitrile;α-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile
62 prices
Selected condition：
Brand
- aablocks
- AK Scientific
- ApexBio Technology
- Apolloscientific
- Arctom
- Axon Medchem
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- TCI Chemical
- Tocris
- TRC
- Usbiological
Package
- 10
- 10mg
- 1
- 1mg
- 5mg
- 50
- 25.00mg
- 25mg
- 50.00mg
- 50mg
- 100mg
- 200mg
- 250mg
- 500mg
- 10mM(in1mLDMSO)
- 10mM*1mLinDMSO(Solution)
- 1g
- 10mM*1mLinDMSO(Solid+Solvent)
- Manufactureraablocks
- Product numberAA0030D9
- Product description3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile 98+%
- Packaging1mg
- Price$12
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0030D9
- Product description3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile 98+%
- Packaging5mg
- Price$23
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0030D9
- Product description3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile 98
- Packaging25mg
- Price$72
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0030D9
- Product description3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile 98
- Packaging50mg
- Price$99
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0030D9
- Product description3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile 98
- Packaging100mg
- Price$151
- Updated2026-05-28
- Buy
- ManufacturerAK Scientific
- Product numberX3440
- Product descriptionSL327
- Packaging50mg
- Price$451
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1894
- Product descriptionSL-327
- Packaging100mg
- Price$264
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA1894
- Product descriptionSL-327
- Packaging25mg
- Price$88
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA1894
- Product descriptionSL-327
- Packaging5mg
- Price$55
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA1894
- Product descriptionSL-327
- Packaging10mM(in1mLDMSO)
- Price$61
- Updated2026-05-06
- Buy
- ManufacturerApolloscientific
- Product numberBISN0193
- Product description3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile
- Packaging5mg
- Price$41
- Updated2026-06-04
- Buy
- ManufacturerApolloscientific
- Product numberBISN0193
- Product description3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile
- Packaging10mg
- Price$153
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0193
- Product description3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile
- Packaging50mg
- Price$522
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberSLK-S1066
- Product descriptionSL-327 100.00%
- Packaging200mg
- Price$549
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberSLK-S1066
- Product descriptionSL-327 100.00%
- Packaging25mg
- Price$257
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberSLK-S1066
- Product descriptionSL-327 100.00%
- Packaging50mg
- Price$330
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA0030D9 | 3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile 98+% | 1mg | $12 | 2026-05-28 | Buy |
| aablocks | AA0030D9 | 3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile 98+% | 5mg | $23 | 2026-05-28 | Buy |
| aablocks | AA0030D9 | 3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile 98 | 25mg | $72 | 2026-05-28 | Buy |
| aablocks | AA0030D9 | 3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile 98 | 50mg | $99 | 2026-05-28 | Buy |
| aablocks | AA0030D9 | 3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile 98 | 100mg | $151 | 2026-05-28 | Buy |
| AK Scientific | X3440 | SL327 | 50mg | $451 | 2021-12-16 | Buy |
| ApexBio Technology | A1894 | SL-327 | 100mg | $264 | 2026-05-06 | Buy |
| ApexBio Technology | A1894 | SL-327 | 25mg | $88 | 2026-05-06 | Buy |
| ApexBio Technology | A1894 | SL-327 | 5mg | $55 | 2026-05-06 | Buy |
| ApexBio Technology | A1894 | SL-327 | 10mM(in1mLDMSO) | $61 | 2026-05-06 | Buy |
| Apolloscientific | BISN0193 | 3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile | 5mg | $41 | 2026-06-04 | Buy |
| Apolloscientific | BISN0193 | 3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile | 10mg | $153 | 2021-12-16 | Buy |
| Apolloscientific | BISN0193 | 3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile | 50mg | $522 | 2021-12-16 | Buy |
| Arctom | SLK-S1066 | SL-327 100.00% | 200mg | $549 | 2026-05-26 | Buy |
| Arctom | SLK-S1066 | SL-327 100.00% | 25mg | $257 | 2026-05-26 | Buy |
| Arctom | SLK-S1066 | SL-327 100.00% | 50mg | $330 | 2026-05-26 | Buy |
Properties
Melting point :127-128.2 °C
Boiling point :512.6±50.0 °C(Predicted)
Density :1.40
storage temp. :2-8°C
solubility :DMSO: 32 mg/mL
form :solid
pka :3.42±0.10(Predicted)
color :white
InChI :1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+
InChIKey :JLOXTZFYJNCPIS-FYWRMAATSA-N
SMILES :N\C(Sc1ccc(N)cc1)=C(\C#N)c2ccccc2C(F)(F)F
Boiling point :512.6±50.0 °C(Predicted)
Density :1.40
storage temp. :2-8°C
solubility :DMSO: 32 mg/mL
form :solid
pka :3.42±0.10(Predicted)
color :white
InChI :1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+
InChIKey :JLOXTZFYJNCPIS-FYWRMAATSA-N
SMILES :N\C(Sc1ccc(N)cc1)=C(\C#N)c2ccccc2C(F)(F)F
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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Description
The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates a diverse array of cellular processes. SL 327 is an inhibitor of MEK1 and MEK2 (IC50s = 0.18 and 0.22 μM), the kinases upstream of ERK1/2. It inhibits ERK1, MKK/p38, MKK4, JNK, and PKC at much higher concentrations (IC50s = >50, 21, >100, >100, >10 μM, respectively). Since SL 327 rapidly passes the blood-brain barrier, it has been used to dissect the effect of RAS/RAF/MEK/ERK signaling pathway inhibition on behavior, including long-term memory, spatial learning, and fear/operant conditioning.More related product prices
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Suppliers and manufacturers
Shanghai Boyle Chemical Co., Ltd.
3B Pharmachem (Wuhan) International Co.,Ltd.
Chembest Research Laboratories Limited
Ascent Scientific
China DongFan Chemical Co.,LTD
Jinan Trio PharmaTech Co., Ltd.
Dalian Meilun Biotech Co., Ltd.
NCE Biomedical Co.,Ltd.
Haoyuan Chemexpress Co., Ltd.
TOKYO CHEMICAL INDUSTRY CO., LTD.