SL 327
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- $12 - $1677
- Product name: SL 327
- CAS: 305350-87-2
- MF: C16H12F3N3S
- MW: 335.35
- EINECS:
- MDL Number:MFCD06411432
- Synonyms:ALPHA-[AMINO[(4-AMINOPHENYL)THIO]METHYLENE]-2-(TRIFLUOROMETHYL)BENZENEACETONITRILE;ALPHA-[AMINO-(4-AMINOPHENYLTHIO)METHYLENE)-2-(TRIFLUOROMETHYL)PHENYLACETONITRILE;SL 327;Z-EPSILON-T E-ALPHA-(AMINO-((4-AMINOPHENYL)THIO)METHYLENE)-2-(TRIFLUOROMETHYL)BENZENEACETONITRILE;Z-AND E-ALPHA-(AMINO-((4-AMINOPHENYL)THIO)METHYLENE)-2-(TRIFLUOROMETHYL)BENZENEACETONITRILE;a-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile;α-[amino-(4-aminophenylthio)methylene)-2-(trifluoromethyl)phenylacetonitrile;α-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile
69 prices
Selected condition：
Brand
- aablocks
- AK Scientific
- ApexBio Technology
- Apolloscientific
- Arctom
- Axon Medchem
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- TCI Chemical
- Tocris
- TRC
- Usbiological
Package
- 10
- 10mg
- 1
- 1mg
- 5mg
- 50
- 25.00mg
- 25mg
- 50.00mg
- 50mg
- 100mg
- 200mg
- 250mg
- 500mg
- 10mM(in1mLDMSO)
- 10mM*1mLinDMSO(Solid+Solvent)
- 1g
- 10mM*1mLinDMSO(Solution)
- Manufactureraablocks
- Product numberAA0030D9
- Product description3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile 98+%
- Packaging1mg
- Price$12
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0030D9
- Product description3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile 98+%
- Packaging5mg
- Price$23
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0030D9
- Product description3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile 98
- Packaging25mg
- Price$72
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0030D9
- Product description3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile 98
- Packaging50mg
- Price$99
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0030D9
- Product description3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile 98
- Packaging100mg
- Price$151
- Updated2026-05-28
- Buy
- ManufacturerAK Scientific
- Product numberX3440
- Product descriptionSL327
- Packaging50mg
- Price$451
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1894
- Product descriptionSL-327
- Packaging100mg
- Price$264
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA1894
- Product descriptionSL-327
- Packaging25mg
- Price$88
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA1894
- Product descriptionSL-327
- Packaging10mM(in1mLDMSO)
- Price$61
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA1894
- Product descriptionSL-327
- Packaging5mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1894
- Product descriptionSL-327
- Packaging5mg
- Price$55
- Updated2026-05-06
- Buy
- ManufacturerApolloscientific
- Product numberBISN0193
- Product description3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile
- Packaging5mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0193
- Product description3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile
- Packaging10mg
- Price$153
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0193
- Product description3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile
- Packaging50mg
- Price$522
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberSLK-S1066
- Product descriptionSL-327 100.00%
- Packaging50mg
- Price$330
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberSLK-S1066
- Product descriptionSL-327 100.00%
- Packaging5mg
- Price$140
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA0030D9 | 3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile 98+% | 1mg | $12 | 2026-05-28 | Buy |
| aablocks | AA0030D9 | 3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile 98+% | 5mg | $23 | 2026-05-28 | Buy |
| aablocks | AA0030D9 | 3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile 98 | 25mg | $72 | 2026-05-28 | Buy |
| aablocks | AA0030D9 | 3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile 98 | 50mg | $99 | 2026-05-28 | Buy |
| aablocks | AA0030D9 | 3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile 98 | 100mg | $151 | 2026-05-28 | Buy |
| AK Scientific | X3440 | SL327 | 50mg | $451 | 2021-12-16 | Buy |
| ApexBio Technology | A1894 | SL-327 | 100mg | $264 | 2026-05-06 | Buy |
| ApexBio Technology | A1894 | SL-327 | 25mg | $88 | 2026-05-06 | Buy |
| ApexBio Technology | A1894 | SL-327 | 10mM(in1mLDMSO) | $61 | 2026-05-06 | Buy |
| ApexBio Technology | A1894 | SL-327 | 5mg | $50 | 2021-12-16 | Buy |
| ApexBio Technology | A1894 | SL-327 | 5mg | $55 | 2026-05-06 | Buy |
| Apolloscientific | BISN0193 | 3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile | 5mg | $95 | 2021-12-16 | Buy |
| Apolloscientific | BISN0193 | 3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile | 10mg | $153 | 2021-12-16 | Buy |
| Apolloscientific | BISN0193 | 3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile | 50mg | $522 | 2021-12-16 | Buy |
| Arctom | SLK-S1066 | SL-327 100.00% | 50mg | $330 | 2026-05-26 | Buy |
| Arctom | SLK-S1066 | SL-327 100.00% | 5mg | $140 | 2026-05-26 | Buy |
Properties
Melting point :127-128.2 °C
Boiling point :512.6±50.0 °C(Predicted)
Density :1.40
storage temp. :2-8°C
solubility :DMSO: 32 mg/mL
form :solid
pka :3.42±0.10(Predicted)
color :white
InChI :1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+
InChIKey :JLOXTZFYJNCPIS-FYWRMAATSA-N
SMILES :N\C(Sc1ccc(N)cc1)=C(\C#N)c2ccccc2C(F)(F)F
Boiling point :512.6±50.0 °C(Predicted)
Density :1.40
storage temp. :2-8°C
solubility :DMSO: 32 mg/mL
form :solid
pka :3.42±0.10(Predicted)
color :white
InChI :1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+
InChIKey :JLOXTZFYJNCPIS-FYWRMAATSA-N
SMILES :N\C(Sc1ccc(N)cc1)=C(\C#N)c2ccccc2C(F)(F)F
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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Description
The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates a diverse array of cellular processes. SL 327 is an inhibitor of MEK1 and MEK2 (IC50s = 0.18 and 0.22 μM), the kinases upstream of ERK1/2. It inhibits ERK1, MKK/p38, MKK4, JNK, and PKC at much higher concentrations (IC50s = >50, 21, >100, >100, >10 μM, respectively). Since SL 327 rapidly passes the blood-brain barrier, it has been used to dissect the effect of RAS/RAF/MEK/ERK signaling pathway inhibition on behavior, including long-term memory, spatial learning, and fear/operant conditioning.More related product prices
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Suppliers and manufacturers
career henan chemical co
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ATK CHEMICAL COMPANY LIMITED
Shandong chuangyingchemical Co., Ltd.
Dideu Industries Group Limited
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
Hangzhou MolCore BioPharmatech Co.,Ltd.
ShenZhen Trendseen Biological Technology Co.,Ltd.
Wuhan Topule Biopharmaceutical Co., Ltd
$1.00
(Z)-3-amino-3-(4-aminophenyl)sulfanyl-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile CAS:305350-87-2
(Z)-3-amino-3-(4-aminophenyl)sulfanyl-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile CAS:305350-87-2
