SP 141
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- $44 - $1700
- Product name: SP 141
- CAS: 1253491-42-7
- MF: C22H16N2O
- MW: 324.38
- EINECS:
- MDL Number:MFCD29059920
- Synonyms:SP 141;6-methoxy-1-(naphthalen-1-yl)-9H-pyrido[3,4-b]indole;9H-Pyrido[3,4-b]indole, 6-methoxy-1-(1-naphthalenyl)-;SP 141;SP141;;6-Methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole;6-Methoxy-1-(1-naphthyl)-9H-β-carboline;pancreatic,SP-141,inhibit,Inhibitor,cancer,MDM-2/p53,breast,degradation,auto-ubiquitination,SP141;SP-141, 10 mM in DMSO
15 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Axon Medchem
- Cayman Chemical
- DC Chemicals
- Tocris
- TRC
- Usbiological
Package
- 50
- 10
- 1mg
- 5mg
- 10mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number5674DP
- Product description6-Methoxy-1-naphthalen-1-yl-9H-pyrido[3,4-b]indole
- Packaging1mg
- Price$147
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number5674DP
- Product description6-Methoxy-1-naphthalen-1-yl-9H-pyrido[3,4-b]indole
- Packaging10mg
- Price$313
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4120
- Product descriptionSP141
- Packaging10mg
- Price$219
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2437
- Product descriptionSP141 99%
- Packaging10mg
- Price$132
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17003
- Product descriptionSP 141 ≥98%
- Packaging1mg
- Price$44
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17003
- Product descriptionSP 141 ≥98%
- Packaging5mg
- Price$118
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17003
- Product descriptionSP 141 ≥98%
- Packaging10mg
- Price$193
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17003
- Product descriptionSP 141 ≥98%
- Packaging50mg
- Price$849
- Updated2024-03-01
- Buy
- ManufacturerDC Chemicals
- Product numberDC8599
- Product descriptionSP141 >98%
- Packaging100mg
- Price$500
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC8599
- Product descriptionSP141 >98%
- Packaging250mg
- Price$900
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC8599
- Product descriptionSP141 >98%
- Packaging1g
- Price$1700
- Updated2021-12-16
- Buy
- ManufacturerTocris
- Product number5332
- Product descriptionSP141 ≥98%(HPLC)
- Packaging10
- Price$208
- Updated2021-12-16
- Buy
- ManufacturerTocris
- Product number5332
- Product descriptionSP141 ≥98%(HPLC)
- Packaging50
- Price$870
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberS678500
- Product descriptionSP141
- Packaging5mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product number256718
- Product descriptionSP 141
- Packaging10mg
- Price$460
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 5674DP | 6-Methoxy-1-naphthalen-1-yl-9H-pyrido[3,4-b]indole | 1mg | $147 | 2021-12-16 | Buy |
| AK Scientific | 5674DP | 6-Methoxy-1-naphthalen-1-yl-9H-pyrido[3,4-b]indole | 10mg | $313 | 2021-12-16 | Buy |
| ApexBio Technology | C4120 | SP141 | 10mg | $219 | 2021-12-16 | Buy |
| Axon Medchem | Axon2437 | SP141 99% | 10mg | $132 | 2021-12-16 | Buy |
| Cayman Chemical | 17003 | SP 141 ≥98% | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 17003 | SP 141 ≥98% | 5mg | $118 | 2024-03-01 | Buy |
| Cayman Chemical | 17003 | SP 141 ≥98% | 10mg | $193 | 2024-03-01 | Buy |
| Cayman Chemical | 17003 | SP 141 ≥98% | 50mg | $849 | 2024-03-01 | Buy |
| DC Chemicals | DC8599 | SP141 >98% | 100mg | $500 | 2021-12-16 | Buy |
| DC Chemicals | DC8599 | SP141 >98% | 250mg | $900 | 2021-12-16 | Buy |
| DC Chemicals | DC8599 | SP141 >98% | 1g | $1700 | 2021-12-16 | Buy |
| Tocris | 5332 | SP141 ≥98%(HPLC) | 10 | $208 | 2021-12-16 | Buy |
| Tocris | 5332 | SP141 ≥98%(HPLC) | 50 | $870 | 2021-12-16 | Buy |
| TRC | S678500 | SP141 | 5mg | $95 | 2021-12-16 | Buy |
| Usbiological | 256718 | SP 141 | 10mg | $460 | 2021-12-16 | Buy |
Properties
Boiling point :571.2±45.0 °C(Predicted)
Density :1.284±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≤100mg/ml in ethanol;30mg/ml in DMSO;50mg/ml in dimethyl formamide
form :crystalline solid
pka :15.04±0.40(Predicted)
color :White to yellow
Density :1.284±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≤100mg/ml in ethanol;30mg/ml in DMSO;50mg/ml in dimethyl formamide
form :crystalline solid
pka :15.04±0.40(Predicted)
color :White to yellow
Safety Information
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Description
Mouse double minute 2 protein (Mdm2) is an E3 ubiquitin-protein ligase that binds and ubiquitinates the tumor suppressor p53, leading to its degradation by the proteasome. SP 141 is a cell-permeable inhibitor of Mdm2 (Ki = 28 nM). Binding of Mdm2 by SP 141 promotes its auto-ubiquitination and proteasomal degradation. SP 141 induces cell cycle arrest and apoptosis in breast and pancreatic cancer cell lines and inhibits xenograft tumor growth in vivo. This compound has a short half-life in plasma and wide tissue distribution in tumor-bearing nude mice.Suppliers and manufacturers
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Tianjin Kailiqi Biotechnology Co., Ltd.
ShangHai Biochempartner Co.,Ltd
