Semagacestat
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- $17 - $3245
- Product name: Semagacestat
- CAS: 425386-60-3
- MF: C19H27N3O4
- MW: 361.44
- EINECS:1592732-453-0
- MDL Number:MFCD09970409
- Synonyms:(2S)-2-HYDROXY-3-METHYL-N-[(2S)-1-{[(1S)-3-METHYL-2-OXO-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPIN-1-YL]AMINO}-1-OXOPROPAN-2-YL]BUTANAMIDE;semagacestat;Butanamide, 2-hydroxy-3-methyl-N-[(1S)-1-methyl-2-oxo-2-[[(1S)-2,3,4,5- tetrahydro-3-methyl-2-oxo-1H-3-benzazepin-1-yl]amino]ethyl]-, (2S)-;(2S)-2-Hydroxy-3-methyl-N-[(1S)-1-methyl-2-oxo-2-[[(1S)-2,3,4,5-tetrahydro-3-methyl-2-oxo-1H-3-benzazepin-1-yl]amino]ethyl]butanamide;Semagacestat/LY-450139;Unii-3yn0602W4w;LY450139(Semagacestat);2-hydroxy-3-Methyl-N-[(1S)-1-Methyl-2-oxo-2-[[(1S)-2
92 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Synthonix
- Tocris
- TRC
- Usbiological
Package
- 5mg
- 0.05g
- 0.1g
- 0.25g
- 0.5g
- 500.00mg
- 1000mg
- 10mM*1mLinDMSO(Solution)
- 25
- 5
- 1.00g
- 5 mg
- 25 mg
- 1mg
- 2mg
- EvaluationSample
- 10mg
- 25mg
- 50mg
- 100mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 200mg
- 250mg
- 500mg
- 1g
- 10mM(in1mLDMSO)
- Manufactureraablocks
- Product numberAA0071SO
- Product descriptionSemagacestat 98%
- Packaging5mg
- Price$30
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0071SO
- Product descriptionSemagacestat 98%
- Packaging1mg
- Price$17
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0071SO
- Product descriptionSemagacestat 98%
- Packaging10mg
- Price$42
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0071SO
- Product descriptionSemagacestat 98%
- Packaging25mg
- Price$76
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0071SO
- Product descriptionSemagacestat 98%
- Packaging50mg
- Price$127
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0071SO
- Product descriptionSemagacestat 98%
- Packaging100mg
- Price$195
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0071SO
- Product descriptionSemagacestat 98%
- Packaging250mg
- Price$365
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0071SO
- Product descriptionSemagacestat 98%
- Packaging500mg
- Price$568
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0071SO
- Product descriptionSemagacestat 98%
- Packaging1g
- Price$894
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product number10792
- Product descriptionSemagacestat 98%
- Packaging100MG
- Price$460
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10792
- Product descriptionSemagacestat 98%
- Packaging25MG
- Price$155
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10792
- Product descriptionSemagacestat 98%
- Packaging1G
- Price$1500
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberX7560
- Product descriptionSemagacestat
- Packaging1mg
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA892738
- Product descriptionSemagacestat 98+%
- Packaging5mg
- Price$59
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA892738
- Product descriptionSemagacestat 98+%
- Packaging1mg
- Price$35
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA892738
- Product descriptionSemagacestat 98+%
- Packaging10mg
- Price$108
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA0071SO | Semagacestat 98% | 5mg | $30 | 2026-05-28 | Buy |
| aablocks | AA0071SO | Semagacestat 98% | 1mg | $17 | 2026-05-28 | Buy |
| aablocks | AA0071SO | Semagacestat 98% | 10mg | $42 | 2026-05-28 | Buy |
| aablocks | AA0071SO | Semagacestat 98% | 25mg | $76 | 2026-05-28 | Buy |
| aablocks | AA0071SO | Semagacestat 98% | 50mg | $127 | 2026-05-28 | Buy |
| aablocks | AA0071SO | Semagacestat 98% | 100mg | $195 | 2026-05-28 | Buy |
| aablocks | AA0071SO | Semagacestat 98% | 250mg | $365 | 2026-05-28 | Buy |
| aablocks | AA0071SO | Semagacestat 98% | 500mg | $568 | 2026-05-28 | Buy |
| aablocks | AA0071SO | Semagacestat 98% | 1g | $894 | 2026-05-28 | Buy |
| ACHEMBLOCK | 10792 | Semagacestat 98% | 100MG | $460 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10792 | Semagacestat 98% | 25MG | $155 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10792 | Semagacestat 98% | 1G | $1500 | 2026-05-27 | Buy |
| AK Scientific | X7560 | Semagacestat | 1mg | $28 | 2021-12-16 | Buy |
| Ambeed | A892738 | Semagacestat 98+% | 5mg | $59 | 2021-12-16 | Buy |
| Ambeed | A892738 | Semagacestat 98+% | 1mg | $35 | 2021-12-16 | Buy |
| Ambeed | A892738 | Semagacestat 98+% | 10mg | $108 | 2021-12-16 | Buy |
Properties
Melting point :208-212 °C
Boiling point :681.9±55.0 °C(Predicted)
Density :1.22
Flash point :366.2℃
storage temp. :2-8°C
solubility :DMSO (Slightly), Dichloromethane (Slightly), Methanol (Slightly)
form :Solid
pka :12.97±0.20(Predicted)
color :White
InChIKey :PKXWXXPNHIWQHW-RCBQFDQVSA-N
SMILES :O=C([C@@H](NC([C@@H](O)C(C)C)=O)C)N[C@@H](C1=CC=CC=C1CCN2C)C2=O
Boiling point :681.9±55.0 °C(Predicted)
Density :1.22
Flash point :366.2℃
storage temp. :2-8°C
solubility :DMSO (Slightly), Dichloromethane (Slightly), Methanol (Slightly)
form :Solid
pka :12.97±0.20(Predicted)
color :White
InChIKey :PKXWXXPNHIWQHW-RCBQFDQVSA-N
SMILES :O=C([C@@H](NC([C@@H](O)C(C)C)=O)C)N[C@@H](C1=CC=CC=C1CCN2C)C2=O
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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Description
γ-Secretase is a protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors and β-amyloid precursor protein (APP), within the transmembrane domain. Semagacestat is a potent inhibitor of γ-secretase that blocks the production of Aβ38, Aβ40, and Aβ42 with IC50 values of 12.0, 12.1, and 10.9 nM, respectively. It also blocks Notch signaling (IC50 = 14.1 nM). Semagacestat modulates γ-secretase activity in vivo, altering Aβ levels in brain, cerebrospinal fluids, and plasma in a dose-dependent fashion. Although semagacestat does not improve cognitive status in humans, it is useful as a pan γ-secretase inhibitor for research purposes.Related product price
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