Simvastatin
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- $5 - $4900
- Product name: Simvastatin
- CAS: 79902-63-9
- MF: C25H38O5
- MW: 418.57
- EINECS:616-751-8
- MDL Number:MFCD00072007
- Synonyms:(1s-(1-alpha,3-dro-4-hydroxy-6-oxo-2h-pyran-2-yl)ethyl)-1-naphthalenyleste ;7-beta,8-beta(2s*,4s*),8a-beta))-alph ;[1S-[1α，3α，7β，8β(2S^<*>^，4S^<*>^)，8αβ]-2，2-Dimethylbutanoic acid 1，2，3，7，8，8α-hexahydro-3，7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-y1)ethyl]-1-naphthyl ester;Lodaiès;[(1S,3R,7R,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxo-oxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoat;Butanoic acid, 2,2-dimethyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro- 4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1-alpha,3-alpha,7- beta,8-beta(2S*,4S*),8a-beta));[8-[2-(4-Hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl]2,2-dimethylbutanoate;2,2-Dimethylbutyric acid (1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalene-1-yl ester
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Brand
- Adipogen Life Sciences
- AHH
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Apolloscientific
- Arctom
- Aronis compounds
- AvaChem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chem-Impex
- ChemScene
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- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
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Package
- s0650000
- 10mg
- 20mg
- 100mg
- 200mg
- 500mg
- 1kg
- y0002069
- 50
- 10mM(in 1mL DMSO)
- 5MG
- 25mg
- 50mg
- 250mg
- 1g
- 5g
- 10g
- 25g
- 100g
- ManufacturerAdipogen Life Sciences
- Product numberAG-CN2-0052-M050
- Product descriptionSimvastatin ≥98%(HPLC)
- Packaging50mg
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerAHH
- Product numberAPI-1626
- Product descriptionSimvastatin 98%
- Packaging1g
- Price$260
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberJ10128
- Product descriptionSimvastatin
- Packaging25mg
- Price$39
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberJ93930
- Product descriptionSimvastatin
- Packaging25g
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA198975
- Product description(1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl2,2-dimethylbutanoate 98+%
- Packaging250mg
- Price$5
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA198975
- Product description(1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl2,2-dimethylbutanoate 98+%
- Packaging1g
- Price$6
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA198975
- Product description(1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl2,2-dimethylbutanoate 98+%
- Packaging5g
- Price$16
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA198975
- Product description(1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl2,2-dimethylbutanoate 98+%
- Packaging10g
- Price$30
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA198975
- Product description(1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl2,2-dimethylbutanoate 98+%
- Packaging25g
- Price$58
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA198975
- Product description(1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl2,2-dimethylbutanoate 98+%
- Packaging100g
- Price$214
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0006193
- Product description6'-EXOMETHYLENE SIMVASTATIN, ACID SODIUM SALT 95.00%
- Packaging5MG
- Price$498.08
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0026083
- Product descriptionSIMCOR 95.00%
- Packaging5MG
- Price$503.35
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8522
- Product descriptionSimvastatin(Zocor)
- Packaging10mM(in 1mL DMSO)
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8522
- Product descriptionSimvastatin(Zocor)
- Packaging50mg
- Price$82
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8522
- Product descriptionSimvastatin(Zocor)
- Packaging250mg
- Price$331
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0115
- Product descriptionSimvastatin
- Packaging10mg
- Price$66
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CN2-0052-M050 | Simvastatin ≥98%(HPLC) | 50mg | $90 | 2021-12-16 | Buy |
| AHH | API-1626 | Simvastatin 98% | 1g | $260 | 2021-12-16 | Buy |
| AK Scientific | J10128 | Simvastatin | 25mg | $39 | 2021-12-16 | Buy |
| AK Scientific | J93930 | Simvastatin | 25g | $70 | 2021-12-16 | Buy |
| Ambeed | A198975 | (1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl2,2-dimethylbutanoate 98+% | 250mg | $5 | 2021-12-16 | Buy |
| Ambeed | A198975 | (1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl2,2-dimethylbutanoate 98+% | 1g | $6 | 2021-12-16 | Buy |
| Ambeed | A198975 | (1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl2,2-dimethylbutanoate 98+% | 5g | $16 | 2021-12-16 | Buy |
| Ambeed | A198975 | (1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl2,2-dimethylbutanoate 98+% | 10g | $30 | 2021-12-16 | Buy |
| Ambeed | A198975 | (1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl2,2-dimethylbutanoate 98+% | 25g | $58 | 2021-12-16 | Buy |
| Ambeed | A198975 | (1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl2,2-dimethylbutanoate 98+% | 100g | $214 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0006193 | 6'-EXOMETHYLENE SIMVASTATIN, ACID SODIUM SALT 95.00% | 5MG | $498.08 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0026083 | SIMCOR 95.00% | 5MG | $503.35 | 2021-12-16 | Buy |
| ApexBio Technology | A8522 | Simvastatin(Zocor) | 10mM(in 1mL DMSO) | $60 | 2021-12-16 | Buy |
| ApexBio Technology | A8522 | Simvastatin(Zocor) | 50mg | $82 | 2021-12-16 | Buy |
| ApexBio Technology | A8522 | Simvastatin(Zocor) | 250mg | $331 | 2021-12-16 | Buy |
| Apolloscientific | BISN0115 | Simvastatin | 10mg | $66 | 2021-12-16 | Buy |
Properties
Melting point :127-132 °C (lit.)
alpha :D25 +292° (c = 0.5% in acetonitrile)
Boiling point :564.9±50.0 °C(Predicted)
Density :1.11±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥20mg/mL
pka :13.49±0.40(Predicted)
form :solid
color :white
optical activity :[α]/D +275±25°, c = 1 in acetonitrile
Merck :14,8539
BCS Class :2
Stability :Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
CAS DataBase Reference :79902-63-9(CAS DataBase Reference)
NIST Chemistry Reference :Simvastatin(79902-63-9)
EPA Substance Registry System :Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester (79902-63-9)
alpha :D25 +292° (c = 0.5% in acetonitrile)
Boiling point :564.9±50.0 °C(Predicted)
Density :1.11±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥20mg/mL
pka :13.49±0.40(Predicted)
form :solid
color :white
optical activity :[α]/D +275±25°, c = 1 in acetonitrile
Merck :14,8539
BCS Class :2
Stability :Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
CAS DataBase Reference :79902-63-9(CAS DataBase Reference)
NIST Chemistry Reference :Simvastatin(79902-63-9)
EPA Substance Registry System :Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester (79902-63-9)
Safety Information
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| Signal word: | Warning | ||||||||||||
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Description
Simvastatin is an HMGCR (HMG-CoA reductase) inhibitor with anti-proliferative properties. This compound has been shown to modulate purified bovine pituitary 20 S proteasome via mild stimulation of chymotrypsin-like activity and inhibition of peptidylglutamylpeptide hydrolyzing activity. Mechanistic studies suggest that Simvastatin decreases CDK4 and CDK2 kinase activities and represses high glucose-induced Rho A (Rho GTPase)/p21 signaling in mesangial cells. Simvastatin also potentiates apoptosis in human myeloid leukemia cells via the suppression of TNF-induced NF-κB activation (IC50 ~ 13 M).More related product prices
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