U 18666A
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- $44 - $2600
- Product name: U 18666A
- CAS: 3039-71-2
- MF: C25H41NO2.ClH
- MW: 424.06
- EINECS:
- MDL Number:MFCD00210908
- Synonyms:U 18666A;3BETA-(2-DIETHYLAMINOETHOXY)ANDROST-5-EN-17 ONE, HCL;3BETA-(2-DIETHYLAMINOETHOXY)-ANDROSTENONE HCL;3BETA-(2-DIETHYLAMINO-ETHOXY)ANDROSTENONE HYDROCHLORIDE;(3BETA)-3-[2-(DIETHYLAMINO)ETHOXY]ANDROST-5-EN-17-ONE DIHYDROCHLORIDE;(3B)-3-[2-(DIETHYLAMINO)ETHOXY]ANDROST-5-EN-17-ONE HYDROCHLORIDE;U18666A,HCl;(3β)-3-[2-(diethylamino)ethoxy]androst-5-en-17-one dihydrochloride
58 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- ApexBio Technology
- Arctom
- AvaChem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- DC Chemicals
- Sigma-Aldrich
- Thermo Scientific Chemicals
- Tocris
- TRC
- Usbiological
Package
- 10mM*1mLinDMSO(Solution)
- 10mM*1mLinDMSO(Solid+Solvent)
- 10mM(1mLinDMSO)
- 1mg
- 2mg
- 10
- 2.5mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250MG
- 1g
- Manufactureraablocks
- Product numberAA002ZW1
- Product description3β-(2-Diethylaminoethoxy)androst-5-en-17-one hydrochloride
- Packaging1mg
- Price$44
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002ZW1
- Product description3β-(2-Diethylaminoethoxy)androst-5-en-17-one hydrochloride
- Packaging2mg
- Price$50
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002ZW1
- Product description3β-(2-Diethylaminoethoxy)androst-5-en-17-one hydrochloride ≥95%
- Packaging5mg
- Price$53
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002ZW1
- Product description3β-(2-Diethylaminoethoxy)androst-5-en-17-one hydrochloride
- Packaging10mg
- Price$95
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002ZW1
- Product description3β-(2-Diethylaminoethoxy)androst-5-en-17-one hydrochloride
- Packaging25mg
- Price$168
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002ZW1
- Product description3β-(2-Diethylaminoethoxy)androst-5-en-17-one hydrochloride
- Packaging50mg
- Price$261
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002ZW1
- Product description3β-(2-Diethylaminoethoxy)androst-5-en-17-one hydrochloride
- Packaging100mg
- Price$383
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberZ238358
- Product descriptionU18666A 98%
- Packaging25MG
- Price$220
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberZ238358
- Product descriptionU18666A 98%
- Packaging100MG
- Price$540
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberZ238358
- Product descriptionU18666A 98%
- Packaging250MG
- Price$1080
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number4494CR
- Product description3beta-(2-Diethylaminoethoxy)androst-5-en-17-onehydrochloride
- Packaging10mg
- Price$197
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6812
- Product descriptionU 18666A
- Packaging25mg
- Price$261
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB6812
- Product descriptionU 18666A
- Packaging10mg
- Price$149
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB6812
- Product descriptionU 18666A
- Packaging50mg
- Price$447
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberHY-107433
- Product descriptionU18666A 99.79%
- Packaging100mg
- Price$523
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberSLK-S9669
- Product descriptionU18666A 99.91%
- Packaging10mM(1mLinDMSO)
- Price$188
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA002ZW1 | 3β-(2-Diethylaminoethoxy)androst-5-en-17-one hydrochloride | 1mg | $44 | 2026-05-28 | Buy |
| aablocks | AA002ZW1 | 3β-(2-Diethylaminoethoxy)androst-5-en-17-one hydrochloride | 2mg | $50 | 2026-05-28 | Buy |
| aablocks | AA002ZW1 | 3β-(2-Diethylaminoethoxy)androst-5-en-17-one hydrochloride ≥95% | 5mg | $53 | 2026-05-28 | Buy |
| aablocks | AA002ZW1 | 3β-(2-Diethylaminoethoxy)androst-5-en-17-one hydrochloride | 10mg | $95 | 2026-05-28 | Buy |
| aablocks | AA002ZW1 | 3β-(2-Diethylaminoethoxy)androst-5-en-17-one hydrochloride | 25mg | $168 | 2026-05-28 | Buy |
| aablocks | AA002ZW1 | 3β-(2-Diethylaminoethoxy)androst-5-en-17-one hydrochloride | 50mg | $261 | 2026-05-28 | Buy |
| aablocks | AA002ZW1 | 3β-(2-Diethylaminoethoxy)androst-5-en-17-one hydrochloride | 100mg | $383 | 2026-05-28 | Buy |
| ACHEMBLOCK | Z238358 | U18666A 98% | 25MG | $220 | 2026-05-27 | Buy |
| ACHEMBLOCK | Z238358 | U18666A 98% | 100MG | $540 | 2026-05-27 | Buy |
| ACHEMBLOCK | Z238358 | U18666A 98% | 250MG | $1080 | 2026-05-27 | Buy |
| AK Scientific | 4494CR | 3beta-(2-Diethylaminoethoxy)androst-5-en-17-onehydrochloride | 10mg | $197 | 2021-12-16 | Buy |
| ApexBio Technology | B6812 | U 18666A | 25mg | $261 | 2026-05-06 | Buy |
| ApexBio Technology | B6812 | U 18666A | 10mg | $149 | 2026-05-06 | Buy |
| ApexBio Technology | B6812 | U 18666A | 50mg | $447 | 2026-05-06 | Buy |
| Arctom | HY-107433 | U18666A 99.79% | 100mg | $523 | 2026-05-26 | Buy |
| Arctom | SLK-S9669 | U18666A 99.91% | 10mM(1mLinDMSO) | $188 | 2026-05-26 | Buy |
Properties
Melting point :195-196.5 °C(lit.)
storage temp. :2-8°C
solubility :H2O: 9 mg/mL at ≤60 °C
form :crystalline
color :white
Water Solubility :Soluble in water at 10mg/ml
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 week.
InChI :1S/C25H41NO2.ClH/c1-5-26(6-2)15-16-28-19-9-7-18-8-10-20-21-11-12-23(27)24(21,3)14-13-22(20)25(18,4)17-19;/h8,19-22H,5-7,9-17H2,1-4H3;1H
InChIKey :ICPRVJHNLABCSA-UHFFFAOYSA-N
SMILES :[Cl-].N(CCOC1CC2(C3C(C4C(CC3)(C(=O)CC4)C)CC=C2CC1)C)(CC)CC.[H+]
storage temp. :2-8°C
solubility :H2O: 9 mg/mL at ≤60 °C
form :crystalline
color :white
Water Solubility :Soluble in water at 10mg/ml
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 week.
InChI :1S/C25H41NO2.ClH/c1-5-26(6-2)15-16-28-19-9-7-18-8-10-20-21-11-12-23(27)24(21,3)14-13-22(20)25(18,4)17-19;/h8,19-22H,5-7,9-17H2,1-4H3;1H
InChIKey :ICPRVJHNLABCSA-UHFFFAOYSA-N
SMILES :[Cl-].N(CCOC1CC2(C3C(C4C(CC3)(C(=O)CC4)C)CC=C2CC1)C)(CC)CC.[H+]
Safety Information
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Description
Impaired trafficking of cholesterol to or from the endoplasmic reticulum (ER) has been implicated in many disease states including Neimann-Pick disease type C (NPC), Alzheimers disease and atherosclerosis. U-18666A is a cell permeable drug that inhibits cholesterol trafficking. It inhibits cholesterol transport from late endosomes/lysosomes to the endoplasmic reticulum (ER), but not cholesterol transport to the plasma membrane as demonstrated in many cell types including macrophages, primary cortical neurons and primary fibroblasts. In macrophages, micromolar concentrations of U-18666A inhibit multiple pathways of cholesterol trafficking from late endosomes, whereas nanomolar concentrations impair cholesterol trafficking to the ER, a response similar to that found in NPC. U-18666A inhibits oxidosqualene cyclase at high (>0.5 mM) concentrations and oral doses (10 mg/kg) induces cataracts in rats.Related product price
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Suppliers and manufacturers
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