UCN-01
|
- $197 - $33422.5
- Product name: UCN-01
- CAS: 112953-11-4
- MF: C28H26N4O4
- MW: 482.53044
- EINECS:
- MDL Number:MFCD26960886
- Synonyms:UCN-01;KW-2401;(9S)-2,3,10,11,12,13-Hexahydro-3α-hydroxy-10α-methoxy-9-methyl-11α-methylamino-9β,13β-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one;9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lM]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-3-hydroxy-10-Methoxy-9-Methyl-11-(MethylaMino)-, (3R,9S,10R,11R,13R)-;KRX-0601;NSC 638850;UNC 01;(5S,6R,7R,9R,16R)-16-Hydroxy-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-17-oxa
18 prices
Selected condition：
Brand
- aablocks
- American Custom Chemicals Corporation
- ApexBio Technology
- Biosynth
- Cayman Chemical
- ChemScene
- CSNpharm
- Sigma-Aldrich
- Usbiological
Package
- 0.25MG
- 0.5mg
- 500μg
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1mg(solution)
- Manufactureraablocks
- Product numberAA008TZ7
- Product descriptionUCN-01 ≥95%
- Packaging1mg
- Price$197
- Updated2026-05-28
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0001444
- Product description7-HYDROXYSTAUROSPORINE 95.00%
- Packaging0.25MG
- Price$218
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4783
- Product descriptionUCN-01
- Packaging1mg(solution)
- Price$287
- Updated2026-05-06
- Buy
- ManufacturerBiosynth
- Product numberMEA95311
- Product descriptionUCN-01
- Packaging0.5mg
- Price$649
- Updated2026-06-04
- Buy
- ManufacturerBiosynth
- Product numberMEA95311
- Product descriptionUCN-01
- Packaging25mg
- Price$6490
- Updated2026-06-04
- Buy
- ManufacturerBiosynth
- Product numberMEA95311
- Product descriptionUCN-01
- Packaging50mg
- Price$8761.5
- Updated2026-06-04
- Buy
- ManufacturerBiosynth
- Product numberMEA95311
- Product descriptionUCN-01
- Packaging100mg
- Price$13629
- Updated2026-06-04
- Buy
- ManufacturerBiosynth
- Product numberMEA95311
- Product descriptionUCN-01
- Packaging250mg
- Price$33422.5
- Updated2026-06-04
- Buy
- ManufacturerCayman Chemical
- Product number18130
- Product descriptionUCN-01 ≥95%
- Packaging1mg
- Price$197
- Updated2026-04-30
- Buy
- ManufacturerChemScene
- Product numberCS-0007545
- Product description7-Hydroxystaurosporine 96.6%
- Packaging1mg
- Price$758
- Updated2026-06-04
- Buy
- ManufacturerChemScene
- Product numberCS-0007545
- Product description7-Hydroxystaurosporine 96.6%
- Packaging5mg
- Price$2351
- Updated2026-06-04
- Buy
- ManufacturerCSNpharm
- Product numberCSN23871
- Product descriptionUCN-01
- Packaging10mg
- Price$4000
- Updated2021-12-16
- Buy
- ManufacturerCSNpharm
- Product numberCSN23871
- Product descriptionUCN-01
- Packaging5mg
- Price$2300
- Updated2021-12-16
- Buy
- ManufacturerCSNpharm
- Product numberCSN23871
- Product descriptionUCN-01
- Packaging1mg
- Price$550
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product numberU6508
- Product descriptionUCN-01 ≥97% (HPLC), powder
- Packaging1mg
- Price$251
- Updated2026-04-30
- Buy
- ManufacturerSigma-Aldrich
- Product number539644
- Product descriptionUCN-01 A cell-permeable Staurosporine derived anticancer agent that reversibly and ATP-competitively inhibits several protein kinases.
- Packaging500μg
- Price$270
- Updated2026-04-30
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA008TZ7 | UCN-01 ≥95% | 1mg | $197 | 2026-05-28 | Buy |
| American Custom Chemicals Corporation | KIN0001444 | 7-HYDROXYSTAUROSPORINE 95.00% | 0.25MG | $218 | 2021-12-16 | Buy |
| ApexBio Technology | C4783 | UCN-01 | 1mg(solution) | $287 | 2026-05-06 | Buy |
| Biosynth | MEA95311 | UCN-01 | 0.5mg | $649 | 2026-06-04 | Buy |
| Biosynth | MEA95311 | UCN-01 | 25mg | $6490 | 2026-06-04 | Buy |
| Biosynth | MEA95311 | UCN-01 | 50mg | $8761.5 | 2026-06-04 | Buy |
| Biosynth | MEA95311 | UCN-01 | 100mg | $13629 | 2026-06-04 | Buy |
| Biosynth | MEA95311 | UCN-01 | 250mg | $33422.5 | 2026-06-04 | Buy |
| Cayman Chemical | 18130 | UCN-01 ≥95% | 1mg | $197 | 2026-04-30 | Buy |
| ChemScene | CS-0007545 | 7-Hydroxystaurosporine 96.6% | 1mg | $758 | 2026-06-04 | Buy |
| ChemScene | CS-0007545 | 7-Hydroxystaurosporine 96.6% | 5mg | $2351 | 2026-06-04 | Buy |
| CSNpharm | CSN23871 | UCN-01 | 10mg | $4000 | 2021-12-16 | Buy |
| CSNpharm | CSN23871 | UCN-01 | 5mg | $2300 | 2021-12-16 | Buy |
| CSNpharm | CSN23871 | UCN-01 | 1mg | $550 | 2021-12-16 | Buy |
| Sigma-Aldrich | U6508 | UCN-01 ≥97% (HPLC), powder | 1mg | $251 | 2026-04-30 | Buy |
| Sigma-Aldrich | 539644 | UCN-01 A cell-permeable Staurosporine derived anticancer agent that reversibly and ATP-competitively inhibits several protein kinases. | 500μg | $270 | 2026-04-30 | Buy |
Properties
Boiling point :705.7±60.0 °C(Predicted)
Density :1.63±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >5mg/mL
form :Tan solid
pka :12.25±0.70(Predicted)
color :light yellow
optical activity :[α]20/D 130 to 160°, c = 0.2 in DMSO
InChIKey :PBCZSGKMGDDXIJ-HQCWYSJUSA-N
SMILES :[n]21c3c4[n](c6c(c4c7c(c3c8c2cccc8)[C@H](NC7=O)O)cccc6)[C@@H]5O[C@]1([C@@H]([C@@H](C5)NC)OC)C
Density :1.63±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >5mg/mL
form :Tan solid
pka :12.25±0.70(Predicted)
color :light yellow
optical activity :[α]20/D 130 to 160°, c = 0.2 in DMSO
InChIKey :PBCZSGKMGDDXIJ-HQCWYSJUSA-N
SMILES :[n]21c3c4[n](c6c(c4c7c(c3c8c2cccc8)[C@H](NC7=O)O)cccc6)[C@@H]5O[C@]1([C@@H]([C@@H](C5)NC)OC)C
Safety Information
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Description
UCN-01 is a synthetic derivative of staurosporine with antiproliferative activity against several in vitro and in vivo cancer models. It inhibits a variety of kinases, including Akt, protein kinase C (IC50 = 30 nM), PDK1 (IC50 = 6 nM) and cyclin-dependent kinases (IC50s = 300-600 nM for Cdk1 and Cdk2). UCN-01 arrests tumor cells in the G1/S phase of the cell cycle and prevents nucleotide excision repair by inhibiting the G2 checkpoint kinase Chk1 (IC50 = 7 nM), leading to apoptosis.Related product price
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