VX-745
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- $27 - $5500
- Product name: VX-745
- CAS: 209410-46-8
- MF: C19H9Cl2F2N3OS
- MW: 436.26
- EINECS:
- MDL Number:MFCD09834070
- Synonyms:6H-PYRIMIDO[1,6-B]PYRIDAZIN-6-ONE, 5-(2,6-DICHLOROPHENYL)-2-[(2,4-DIFLUOROPHENYL)THIO]- (9CI);6H-PYRIMIDO[1,6-B]PYRIDAZIN-6-ONE, 5-(2,6-DICHLOROPHENYL)-2-[(2,4-DIFLUOROPHENYL)THIO]-;5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one;5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyridazino[6,1-f]pyrimidin-6-one;5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenylsulfanyl)-6H-pyriMido[3,4-b]pyridazin-6-one;VX-745(VX 745);5-(2,6-Dichloro-phenyl)-2-(2,4-difluoro-phenylsulfanyl)-1,7,8a-triaza-naphthalen-6-one;5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyridazino[6,1-f]pyrimidin-6-one VX-745
37 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- ApexBio Technology
- Apolloscientific
- Arctom
- Axon Medchem
- Biosynth Carbosynth
- Cayman Chemical
- Chemcia Scientific
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TRC
Package
- 1mg
- 5mg
- 2x5mg
- 10mg
- 25mg
- 50mg
- 250mg
- 500mg
- 1g
- 2g
- 5G
- 10g
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3754-M010
- Product descriptionVX-745 ≥95%
- Packaging10mg
- Price$140
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN1123
- Product descriptionVX745
- Packaging1mg
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN1123
- Product descriptionVX745
- Packaging50mg
- Price$640
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA189058
- Product descriptionVX-745 98+%
- Packaging5mg
- Price$75
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA189058
- Product descriptionVX-745 98+%
- Packaging10mg
- Price$126
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA189058
- Product descriptionVX-745 98+%
- Packaging50mg
- Price$320
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA189058
- Product descriptionVX-745 98+%
- Packaging1g
- Price$2370
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8686
- Product descriptionVX-745
- Packaging50mg
- Price$434
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0180
- Product descriptionVX-745
- Packaging5mg
- Price$73
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0180
- Product descriptionVX-745
- Packaging10mg
- Price$124
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0180
- Product descriptionVX-745
- Packaging50mg
- Price$312
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS469813
- Product descriptionVX-745
- Packaging50mg
- Price$317
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1811
- Product descriptionVX745 99%
- Packaging2x5mg
- Price$154
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD139233
- Product description5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-B]pyridazine-6-one
- Packaging500mg
- Price$550
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD139233
- Product description5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-B]pyridazine-6-one
- Packaging1g
- Price$900
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD139233
- Product description5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-B]pyridazine-6-one
- Packaging2g
- Price$1600
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CR1-3754-M010 | VX-745 ≥95% | 10mg | $140 | 2021-12-16 | Buy |
| AK Scientific | SYN1123 | VX745 | 1mg | $100 | 2021-12-16 | Buy |
| AK Scientific | SYN1123 | VX745 | 50mg | $640 | 2021-12-16 | Buy |
| Ambeed | A189058 | VX-745 98+% | 5mg | $75 | 2021-12-16 | Buy |
| Ambeed | A189058 | VX-745 98+% | 10mg | $126 | 2021-12-16 | Buy |
| Ambeed | A189058 | VX-745 98+% | 50mg | $320 | 2021-12-16 | Buy |
| Ambeed | A189058 | VX-745 98+% | 1g | $2370 | 2021-12-16 | Buy |
| ApexBio Technology | A8686 | VX-745 | 50mg | $434 | 2021-12-16 | Buy |
| Apolloscientific | BISN0180 | VX-745 | 5mg | $73 | 2021-12-16 | Buy |
| Apolloscientific | BISN0180 | VX-745 | 10mg | $124 | 2021-12-16 | Buy |
| Apolloscientific | BISN0180 | VX-745 | 50mg | $312 | 2021-12-16 | Buy |
| Arctom | AS469813 | VX-745 | 50mg | $317 | 2021-12-16 | Buy |
| Axon Medchem | Axon1811 | VX745 99% | 2x5mg | $154 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD139233 | 5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-B]pyridazine-6-one | 500mg | $550 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD139233 | 5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-B]pyridazine-6-one | 1g | $900 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD139233 | 5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-B]pyridazine-6-one | 2g | $1600 | 2021-12-16 | Buy |
Properties
Melting point :261-264 °C
Boiling point :578.9±60.0 °C(Predicted)
Density :1.55±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :≥21.8 mg/mL in DMSO; insoluble in H2O; ≥2.1 mg/mL in EtOH with gentle warming and ultrasonic
form :powder
pka :-0.97±0.40(Predicted)
color :white to beige
Boiling point :578.9±60.0 °C(Predicted)
Density :1.55±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :≥21.8 mg/mL in DMSO; insoluble in H2O; ≥2.1 mg/mL in EtOH with gentle warming and ultrasonic
form :powder
pka :-0.97±0.40(Predicted)
color :white to beige
Safety Information
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Description
p38α is a member of the mitogen-activated protein kinase (MAPK) family of serine/threonine protein kinases. It is widely expressed in endothelial, immune, and inflammatory cells and plays a central role in the regulation of proinflammatory cytokine production including TNF-α, IL-1β, and IL-6. VX-745 is a potent inhibitor of p38α MAPK (IC50 = 10 nM) with 20-fold selectivity over p38β and 1000-fold selectivity over closely related kinases, ERK1 and JNK1-3. It blocks IL-1β and TNF-α release in whole blood in vitro with IC50 values of 150 and 180 nM, respectively. VX-745 has been shown to demonstrate anti-inflammatory efficacy in an animal model of rheumatoid arthritis, but was discontinued in clinical trial due to adverse central nervous system effects.More related product prices
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Suppliers and manufacturers
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