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ChemicalBook >> CAS DataBase List >> VcMMAE

VcMMAE

VcMMAE price.
  • $28 - $6247.5
  • Product name: VcMMAE
  • CAS: 646502-53-6
  • MF: C68H105N11O15
  • MW: 1316.63
  • EINECS:
  • MDL Number:MFCD25372036
  • Synonyms:VcMMAE;Maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl-monomethyl auristatin E;4-((S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)-5-ureidopentanamido)benzyl((S)-1-(((S)-1-(((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-y;MC-VC-PAB-MMAE,MC-Val-Cit-PAB-MMAE;maleimido-caproyl-val-Cit-PAB-MMAE;VeMMAE;EOS-60990;4-((S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)-5-Uriedidopenamiamido)benzyl((S)-1-(((S)-1-(((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S),2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-y
Price87 Properties Safety Information Description
87 prices
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Brand
  • aablocks
  • ACHEMBLOCK
  • Ambeed
  • Arctom
  • Biorbyt Ltd
  • BroadPharm
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
Package
  • 1mg
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  • 25mg
  • 50.00mg
  • 50mg
  • 100mg
  • 250mg
  • 500mg
  • 1g
  • 5g
  • Manufactureraablocks
  • Product numberAA0035PP
  • Product descriptionMaleimidocaproyl-valine-citrulline-p-aminobenzyloxycarbonyl monomethylauristatin E ≥98%
  • Packaging1mg
  • Price$28
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA0035PP
  • Product descriptionMaleimidocaproyl-valine-citrulline-p-aminobenzyloxycarbonyl monomethylauristatin E 98%
  • Packaging5mg
  • Price$36
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA0035PP
  • Product descriptionMaleimidocaproyl-valine-citrulline-p-aminobenzyloxycarbonyl monomethylauristatin E 98%
  • Packaging10mg
  • Price$64
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA0035PP
  • Product descriptionMaleimidocaproyl-valine-citrulline-p-aminobenzyloxycarbonyl monomethylauristatin E
  • Packaging25mg
  • Price$151
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA0035PP
  • Product descriptionMaleimidocaproyl-valine-citrulline-p-aminobenzyloxycarbonyl monomethylauristatin E 98%
  • Packaging50mg
  • Price$187
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA0035PP
  • Product descriptionMaleimidocaproyl-valine-citrulline-p-aminobenzyloxycarbonyl monomethylauristatin E 98%
  • Packaging100mg
  • Price$255
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA0035PP
  • Product descriptionMaleimidocaproyl-valine-citrulline-p-aminobenzyloxycarbonyl monomethylauristatin E 98%
  • Packaging250mg
  • Price$370
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA0035PP
  • Product descriptionMaleimidocaproyl-valine-citrulline-p-aminobenzyloxycarbonyl monomethylauristatin E 98%
  • Packaging1g
  • Price$1192
  • Updated2026-05-28
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  • ManufacturerACHEMBLOCK
  • Product numberQ70231
  • Product descriptionMc-Val-Cit-PAB-MMAE 97%
  • Packaging100MG
  • Price$440
  • Updated2026-05-27
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  • ManufacturerACHEMBLOCK
  • Product numberQ70231
  • Product descriptionMc-Val-Cit-PAB-MMAE 97%
  • Packaging25MG
  • Price$150
  • Updated2026-05-27
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  • ManufacturerACHEMBLOCK
  • Product numberQ70231
  • Product descriptionMc-Val-Cit-PAB-MMAE 97%
  • Packaging5MG
  • Price$45
  • Updated2026-05-27
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  • ManufacturerACHEMBLOCK
  • Product numberQ70231
  • Product descriptionMc-Val-Cit-PAB-MMAE 97%
  • Packaging1G
  • Price$2450
  • Updated2026-05-27
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  • ManufacturerAmbeed
  • Product numberA153774
  • Product descriptionVcMMAE 98+%
  • Packaging25mg
  • Price$1760
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA153774
  • Product descriptionVcMMAE 98+%
  • Packaging1mg
  • Price$210
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA153774
  • Product descriptionVcMMAE 98+%
  • Packaging10mg
  • Price$955
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA153774
  • Product descriptionVcMMAE 98+%
  • Packaging5mg
  • Price$570
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA0035PP Maleimidocaproyl-valine-citrulline-p-aminobenzyloxycarbonyl monomethylauristatin E ≥98% 1mg $28 2026-05-28 Buy
aablocks AA0035PP Maleimidocaproyl-valine-citrulline-p-aminobenzyloxycarbonyl monomethylauristatin E 98% 5mg $36 2026-05-28 Buy
aablocks AA0035PP Maleimidocaproyl-valine-citrulline-p-aminobenzyloxycarbonyl monomethylauristatin E 98% 10mg $64 2026-05-28 Buy
aablocks AA0035PP Maleimidocaproyl-valine-citrulline-p-aminobenzyloxycarbonyl monomethylauristatin E 25mg $151 2026-05-28 Buy
aablocks AA0035PP Maleimidocaproyl-valine-citrulline-p-aminobenzyloxycarbonyl monomethylauristatin E 98% 50mg $187 2026-05-28 Buy
aablocks AA0035PP Maleimidocaproyl-valine-citrulline-p-aminobenzyloxycarbonyl monomethylauristatin E 98% 100mg $255 2026-05-28 Buy
aablocks AA0035PP Maleimidocaproyl-valine-citrulline-p-aminobenzyloxycarbonyl monomethylauristatin E 98% 250mg $370 2026-05-28 Buy
aablocks AA0035PP Maleimidocaproyl-valine-citrulline-p-aminobenzyloxycarbonyl monomethylauristatin E 98% 1g $1192 2026-05-28 Buy
ACHEMBLOCK Q70231 Mc-Val-Cit-PAB-MMAE 97% 100MG $440 2026-05-27 Buy
ACHEMBLOCK Q70231 Mc-Val-Cit-PAB-MMAE 97% 25MG $150 2026-05-27 Buy
ACHEMBLOCK Q70231 Mc-Val-Cit-PAB-MMAE 97% 5MG $45 2026-05-27 Buy
ACHEMBLOCK Q70231 Mc-Val-Cit-PAB-MMAE 97% 1G $2450 2026-05-27 Buy
Ambeed A153774 VcMMAE 98+% 25mg $1760 2021-12-16 Buy
Ambeed A153774 VcMMAE 98+% 1mg $210 2021-12-16 Buy
Ambeed A153774 VcMMAE 98+% 10mg $955 2021-12-16 Buy
Ambeed A153774 VcMMAE 98+% 5mg $570 2021-12-16 Buy
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Properties

Boiling point :1347.6±65.0 °C(Predicted)
Density :1.196±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,Room Temperature
solubility :Soluble in DMSO, DCM, DMF
form :A solid
pka :13.29±0.70(Predicted)
color :White to off-white
InChIKey :NLMBVBUNULOTNS-NNNQBTKHNA-N

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

VcMMAE is a MMAE derivative with valine-citrulline (Vc) linker. VcMMAE can be used to make antibody drug conjugate. VcMMAE is a anti-mitotic agent, monomethyl auristatin E (MMAE), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc). Monomethyl auristatin E (MMAE) is a synthetic antineoplastic agent. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (MAB) which directs it to the cancer cells. In International Nonproprietary Names for MMAE-MAB-conjugates, the name vedotin refers to MMAE plus its linking structure to the antibody. It is a potent antimitotic drug derived from peptides occurring in marine shell-less mollusc Dolabella auricularia called dolastatins which show potent activity in preclinical studies, both in vitro and in vivo, against a range of lymphomas, leukemia and solid tumors. These drugs show potency of up to 200 times that of vinblastine, another antimitotic drug used for Hodgkin lymphoma as well as other types of cancer?

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(3R,4S,5S)-tert-butyl 3-Methoxy-5-Methyl-4-(MethylaMino)heptanoate hydroc hloride MonoMethyl auristatin E ((2R,3R)-3-((S)-1-(tertbutoxycarbonyl)pyrrolidin-2-yl)-3-Methoxy-2-Methylpropanoic acid MonoMethylauristatin F

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Suppliers and manufacturers

career henan chemical co
VcMMAE
$6.00 /1KG
VcMMAE CAS:646502-53-6
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