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ChemicalBook >> CAS DataBase List >> cpi-637

cpi-637

cpi-637 price.
  • $32 - $1800
  • Product name: cpi-637
  • CAS: 1884712-47-3
  • MF: C22H22N6O
  • MW: 386.45
  • EINECS:-0
  • MDL Number:MFCD30489741
  • Synonyms:CPI-637;CPI 637;CPI637;2H-1,5-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-4-methyl-6-[1-methyl-3-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-5-yl]-, (4R)-;CPI-637 >=98% (HPLC);(R)-4-Methyl-6-(1-methyl-3-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-5-yl)-4,5-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one;Inhibitor,inhibit,HAT,Epigenetic Reader Domain,CPI637,CPI-637,Histone Acetyltransferase,HATs;CPI-637, 10 mM in DMSO;CPI-637/1884712-47-3/98%
11 prices
Selected condition:
Brand
  • AK Scientific
  • ApexBio Technology
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number5781EG
  • Product description(4R)-4-Methyl-6-[1-methyl-3-(1-methylpyrazol-4-yl)indazol-5-yl]-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one
  • Packaging25mg
  • Price$479
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7801
  • Product descriptionCPI-637
  • Packaging50mg
  • Price$348
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number23500
  • Product descriptionCPI-637 ≥98%
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number23500
  • Product descriptionCPI-637 ≥98%
  • Packaging5mg
  • Price$122
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number23500
  • Product descriptionCPI-637 ≥98%
  • Packaging10mg
  • Price$169
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number23500
  • Product descriptionCPI-637 ≥98%
  • Packaging25mg
  • Price$343
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5946
  • Product descriptionCPI-637 99.94%
  • Packaging5mg
  • Price$96
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5946
  • Product descriptionCPI-637 99.94%
  • Packaging50mg
  • Price$480
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10477
  • Product descriptionCPI-637 >98%
  • Packaging100mg
  • Price$500
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10477
  • Product descriptionCPI-637 >98%
  • Packaging250mg
  • Price$900
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10477
  • Product descriptionCPI-637 >98%
  • Packaging1g
  • Price$1800
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 5781EG (4R)-4-Methyl-6-[1-methyl-3-(1-methylpyrazol-4-yl)indazol-5-yl]-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one 25mg $479 2021-12-16 Buy
ApexBio Technology B7801 CPI-637 50mg $348 2021-12-16 Buy
Cayman Chemical 23500 CPI-637 ≥98% 1mg $32 2024-03-01 Buy
Cayman Chemical 23500 CPI-637 ≥98% 5mg $122 2024-03-01 Buy
Cayman Chemical 23500 CPI-637 ≥98% 10mg $169 2024-03-01 Buy
Cayman Chemical 23500 CPI-637 ≥98% 25mg $343 2024-03-01 Buy
ChemScene CS-5946 CPI-637 99.94% 5mg $96 2021-12-16 Buy
ChemScene CS-5946 CPI-637 99.94% 50mg $480 2021-12-16 Buy
DC Chemicals DC10477 CPI-637 >98% 100mg $500 2021-12-16 Buy
DC Chemicals DC10477 CPI-637 >98% 250mg $900 2021-12-16 Buy
DC Chemicals DC10477 CPI-637 >98% 1g $1800 2021-12-16 Buy

Properties

Boiling point :689.2±55.0 °C(Predicted)
Density :1.38±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in EtOH; insoluble in H2O; ≥19.3 mg/mL in DMSO with gentle warming
form :solid
pka :14.62±0.40(Predicted)
color :White to off-white
optical activity :[α]/D -39 to -49°, c =1.0 in chloroform-d
InChI :InChI=1S/C22H22N6O/c1-13-9-20(29)25-18-6-4-5-16(22(18)24-13)14-7-8-19-17(10-14)21(26-28(19)3)15-11-23-27(2)12-15/h4-8,10-13,24H,9H2,1-3H3,(H,25,29)/t13-/m1/s1
InChIKey :BFTKDWYIRJGJCA-CYBMUJFWSA-N
SMILES :N1C2=CC=CC(C3C=CC4=C(C=3)C(C3=CN(C)N=C3)=NN4C)=C2N[C@H](C)CC1=O

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

CPI-637 is an inhibitor of cyclic-AMP response element binding protein (CBP) and adenoviral E1A binding protein of 300 kDa (EP300), a homologous pair of bromodomain-containing proteins (IC50s = 30 and 51 nM in a time-resolved-FRET (TR-FRET) assay). It is selective for CBP and EP300 over the BET family of bromodomains (IC50s = >10 μM), however, CPI-637 is active at bromodomain BRD9 (IC50 = 0.73 μM). CPI-637 also inhibits MYC expression (EC50 = 0.6 μM) in AMO-1 cells.