N-メチル-1H-イミダゾール-4-エタンアミン·2塩酸塩
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- ￥27600 - ￥145000
- 化学名: N-メチル-1H-イミダゾール-4-エタンアミン·2塩酸塩
- 英語名: NALPHA-METHYLHISTAMINE DIHYDROCHLORIDE
- 別名:N-メチル-1H-イミダゾール-4-エタンアミン·2塩酸塩;N-メチルヒスタミン二塩酸塩;NΑ-メチルヒスタミン DIHYDROCHLORIDE;N-メチル-1H-イミダゾール-4-エタンアミン・2塩酸塩
- CAS番号: 16503-22-3
- 分子式: C6H11N3.2HCl
- 分子量: 0
- EINECS:
- MDL Number:MFCD00134838
4物価
選択条件：
ブランド
- 富士フイルム和光純薬株式会社(wako)
- Sigma-Aldrich Japan
パッケージ
- 10mg
- 50mg
- 生産者富士フイルム和光純薬株式会社(wako)
- 製品番号W01TOC0573
- 製品説明Nα-メチルヒスタミン dihydrochloride
- 英語製品説明Na-Methylhistamine dihydrochloride
- 包装単位10mg
- 価格￥34000
- 更新しました2021-03-23
- 購入
- 生産者富士フイルム和光純薬株式会社(wako)
- 製品番号W01TOC0573
- 製品説明Nα-メチルヒスタミン dihydrochloride
- 英語製品説明Na-Methylhistamine dihydrochloride
- 包装単位50mg
- 価格￥145000
- 更新しました2021-03-23
- 購入
- 生産者Sigma-Aldrich Japan
- 製品番号H5914
- 製品説明 solid
- 英語製品説明Nα-Methylhistamine dihydrochloride solid
- 包装単位10mg
- 価格￥27600
- 更新しました2024-03-01
- 購入
- 生産者Sigma-Aldrich Japan
- 製品番号H5914
- 製品説明 solid
- 英語製品説明Nα-Methylhistamine dihydrochloride solid
- 包装単位50mg
- 価格￥79000
- 更新しました2024-03-01
- 購入
| 生産者 | 製品番号 | 製品説明 | 包装単位 | 価格 | 更新時間 | 購入 |
|---|---|---|---|---|---|---|
| 富士フイルム和光純薬株式会社(wako) | W01TOC0573 | Nα-メチルヒスタミン dihydrochloride Na-Methylhistamine dihydrochloride |
10mg | ￥34000 | 2021-03-23 | 購入 |
| 富士フイルム和光純薬株式会社(wako) | W01TOC0573 | Nα-メチルヒスタミン dihydrochloride Na-Methylhistamine dihydrochloride |
50mg | ￥145000 | 2021-03-23 | 購入 |
| Sigma-Aldrich Japan | H5914 | solid Nα-Methylhistamine dihydrochloride solid |
10mg | ￥27600 | 2024-03-01 | 購入 |
| Sigma-Aldrich Japan | H5914 | solid Nα-Methylhistamine dihydrochloride solid |
50mg | ￥79000 | 2024-03-01 | 購入 |
プロパティ
融点 :173-176°C
貯蔵温度 :2-8°C
溶解性 :H2O: >20mg/mL
外見 :solid
色 :white
水溶解度 :Soluble to 100 mM in water
安定性： :Hygroscopic
InChI :1S/C6H11N3.2ClH/c1-7-3-2-6-4-8-5-9-6;;/h4-5,7H,2-3H2,1H3,(H,8,9);2*1H
InChIKey :AYUQICXJAMPXPF-UHFFFAOYSA-N
SMILES :Cl[H].Cl[H].CNCCc1c[nH]cn1
貯蔵温度 :2-8°C
溶解性 :H2O: >20mg/mL
外見 :solid
色 :white
水溶解度 :Soluble to 100 mM in water
安定性： :Hygroscopic
InChI :1S/C6H11N3.2ClH/c1-7-3-2-6-4-8-5-9-6;;/h4-5,7H,2-3H2,1H3,(H,8,9);2*1H
InChIKey :AYUQICXJAMPXPF-UHFFFAOYSA-N
SMILES :Cl[H].Cl[H].CNCCc1c[nH]cn1
安全情報
| 絵表示(GHS): |
 
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説明
Production of N-alpha-methyl-histamine, which is a histamine 3 receptor (H3R) agonist, is promoted in Helicobacter pylori infected human gastric mucosa. NAMH acts directly on H2Rs in animals to stimulate acid secretion and to be a H2R agonist. NAMH dose dependently stimulated cAMP productions in CHO-H2R cells. This production was inhibited by famotidine but not by thioperamide. Control CHO cells were unresponsive to either histamine or NAMH. In addition, the effect of NAMH, in terms of cAMP production in CHO-H2R cells, was more potent than that of histamine-that is, with a lower EC50 concentration and higher maximal cAMP production. Both NAMH and histamine, but not R-alpha-methyl-histamine, effectively inhibited [(3)H] tiotidine binding to CHO-H2R cells. These results confirm that NAMH, which is produced in the gastric mucosa by H pylori, is a potent H2R agonist as well as a H3R agonist.供給者とメーカー
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