155206-00-1 Basic information More..
Product Name:Bimatoprost
Synonyms:Beme Prostaglandin;Bima;Bimatoprost (W.S);N-ETHYL-9ALPHA,11ALPHA,15S-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROSTA-5Z, 13E-DIEN-1-AMIDE;LUMIGAN;bimatoprost powder;BIMATOPROST;BIMATOPROST(TM)
CAS:155206-00-1
MF:C25H37NO4
MW:415.57
EINECS:642-890-9
Mol File:155206-00-1.mol
155206-00-1

Use

Bimatoprost was first introduced in the US and Brazil as Lumigan?, an ophthalmic solution (0.03%) for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension, a proven risk of glaucomatous visual field loss. Bitamoprost is a new agent belonging to the PGF2α analog class of prostamides launched in this indication after latanoprost, the most efficaceous topical medication currently available. This synthetic fatty acid amide can be prepared by esterification of 17- phenyl-18,19,20-trinorprostaglandin F2α followed by ethylamidation. Bimatoprost, as related prostamides, is devoid of typical activities associated with PGF2,, analogs; it exhibits a unique pharmacological profile in contracting the feline iris sphincter with an EC50 of 34 nM without interacting with any known prostanoid receptors. Thus it mimics the action of endogenous prostamides on specific receptors that lower IOP by increasing aqueous humor outflow through both pressure-insensitive and pressure-sensitive pathways without reducing humor formation. In a 3-month controlled clinical trial of efficacy and safety in patients with elevated IOP, bimatoprost demonstrated lower mean intraocular pressures at every time point throughout the study, as well as a good tolerance and systemic safety profile compared to latanoprost.

Lastest Price from Bimatoprost manufacturers

  • bimatoprost
  • US $0.10-0.10 / KG
  • 2020-03-16
  • CAS:155206-00-1
  • Min. Order: 10g
  • Purity: 99%+
  • Supply Ability: 10000KG
  • Bimatoprost
  • US $1.00 / KG
  • 2020-03-06
  • CAS:155206-00-1
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 200kgs
  • Bimatoprost
  • US $10.00 / KG
  • 2019-12-02
  • CAS:155206-00-1
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 10 mt
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