| | 133407-86-0 Basic information More.. |
| Product Name: | MG-115 | | Synonyms: | PROTEASOME INHIBITOR MG-115;N-CBZ-LEU-LEU-NORVALINAL;MG-115;Z-LL-NVA-CHO;Z-LEU-LEU-NVA-ALDEHYDE;Z-LEU-LEU-NVA-CHO;Z-LEU-LEU-NVA-H;Z-LEU-LEU-NVA-H (ALDEHYDE) | | CAS: | 133407-86-0 | | MF: | C25H39N3O5 | | MW: | 461.59 | | EINECS: | | | Mol File: | 133407-86-0.mol |  |
Use
(S)-MG115 is a potent and reversible proteasome inhibitor, targeting the chymotryptic site on the 20S particle (Ki = 21 nM). It reduces the degradation of ubiquitin-conjugated proteins in extracts. (S)-MG115 also blocks the degradation of long- and short-lived proteins in intact cells as well as the proteolytic generation of diverse proteins, including NF-κB, antigens, and p53. Proteasome inhibitors, including (S)-MG115, can induce a heat shock response and apoptosis, particularly in cancer cells.[Cayman Chemical]
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133407-86-0
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