101574-65-6 Basic information More..
Product Name:4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE
Synonyms:(E)-4-hydroxy-N'-(4-isopropylbenzylidene)benzohydrazide;4-Hydroxybenzoic acid 2-[[4-(1-methylethyl)phenyl]methylene]hydrazide;4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE;2-[[4-(1-Methylethyl)phenyl]methylene]hydrazide 4-hydroxybenzoic acid;4-hydroxy-N'-(4-isopropylbenzylidene)benzohydrazide;CS-1084;Benzoic acid, 4-hydroxy-, 2-[[4-(1-methylethyl)phenyl]methylene]hydrazide;4-hydroxy-N'-(4-isopropylphenyl‐ methylidene)-benzohydrazide
CAS:101574-65-6
MF:C17H18N2O2
MW:282.34
EINECS:
Mol File:101574-65-6.mol
101574-65-6

Use

The estrogen-related receptors (ERRs) are orphan nuclear receptors with homology to the estrogen receptor family and are expressed in tissues with high metabolic demand. Binding of peroxisome proliferator-activated receptor γ-coactivator 1α (PGC-1α) to this class of receptors is known to potentiate ERR activity. GSK4716 is an ERRβ/γ agonist (IC50 = 2 μM) that can activate the receptor with similar potency as the protein ligand, PGC-1α. It is more than 50-fold selective for binding to ERRβ/γ compared with the estrogen receptors. This compound has been used to demonstrate the contribution of ERR receptor activity to the regulation of mitochondrial activity in skeletal muscle during exercise.[Cayman Chemical]

4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE manufacturers

  • GSK-4716
  • US $58.00-252.00 / mg
  • 2025-05-26
  • CAS:101574-65-6
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  • Purity: 98%
  • Supply Ability: 10g
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