163451-81-8 Basic information More..
Product Name:A77 1726
Synonyms:A 1726;HMR 1726;(Z)-2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide;LeflunoMide EP IMpurity B;Leflunomide Impurity 2(Leflunomide EP Impurity B);A-771726;A 771726;A771726;A-771726;A 77-1726;A771726;HMR-1726;(2Z)-2-Cyano-3-hydroxy-N-[4-(triflu
CAS:163451-81-8
MF:C12H9F3N2O2
MW:270.21
EINECS:642-273-4
Mol File:163451-81-8.mol
163451-81-8

Use

A-771726 is the active metabolite of leflunomide, a prodrug approved by the FDA for treatment of rheumatoid arthritis. A-771726 reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines. It prevents activated lymphocytes from accumulating sufficient pyrimidines to support DNA synthesis (IC50s = 0.09, 3.5, and 12.5 μM for rat, mouse, and human, respectively). At higher doses, A-771726 inhibits tyrosine kinases responsible for early T cell and B cell signaling in the G0/G1 phase of the cell cycle. A-771726 has also been shown to inhibit the production of prostaglandin E2 in synoviocytes activated by TNF-α and IL-1α (IC50s = 7 and 3 μM, respectively) as well as inhibit MMP-1 and IL-6 production at concentrations >10 μM.[Cayman Chemical]

A77 1726 manufacturers

  • teriflunomide
  • US $0.00-0.00 / kg
  • 2025-07-11
  • CAS:163451-81-8
  • Min. Order: 1kg
  • Purity: 99% up by HPLC
  • Supply Ability: 20tons
  • Teriflunomide
  • US $0.00-0.00 / Kg/Drum
  • 2025-07-04
  • CAS:163451-81-8
  • Min. Order: 1KG
  • Purity: 98%min
  • Supply Ability: 1000KGS
  • A77 1726
  • US $3.00 / kg
  • 2025-05-26
  • CAS:163451-81-8
  • Min. Order: 1kg
  • Purity: 0.99
  • Supply Ability: 10000
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