| | 163451-81-8 Basic information More.. |
| Product Name: | A77 1726 | | Synonyms: | A 1726;HMR 1726;(Z)-2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide;LeflunoMide EP IMpurity B;Leflunomide Impurity 2(Leflunomide EP Impurity B);A-771726;A 771726;A771726;A-771726;A 77-1726;A771726;HMR-1726;(2Z)-2-Cyano-3-hydroxy-N-[4-(triflu | | CAS: | 163451-81-8 | | MF: | C12H9F3N2O2 | | MW: | 270.21 | | EINECS: | 642-273-4 | | Mol File: | 163451-81-8.mol |  |
Use
A-771726 is the active metabolite of leflunomide, a prodrug approved by the FDA for treatment of rheumatoid arthritis. A-771726 reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines. It prevents activated lymphocytes from accumulating sufficient pyrimidines to support DNA synthesis (IC50s = 0.09, 3.5, and 12.5 μM for rat, mouse, and human, respectively). At higher doses, A-771726 inhibits tyrosine kinases responsible for early T cell and B cell signaling in the G0/G1 phase of the cell cycle. A-771726 has also been shown to inhibit the production of prostaglandin E2 in synoviocytes activated by TNF-α and IL-1α (IC50s = 7 and 3 μM, respectively) as well as inhibit MMP-1 and IL-6 production at concentrations >10 μM.[Cayman Chemical]
- teriflunomide
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- US $0.00-0.00 / kg
- 2025-07-11
- CAS:163451-81-8
- Min. Order: 1kg
- Purity: 99% up by HPLC
- Supply Ability: 20tons
- Teriflunomide
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- US $0.00-0.00 / Kg/Drum
- 2025-07-04
- CAS:163451-81-8
- Min. Order: 1KG
- Purity: 98%min
- Supply Ability: 1000KGS
- A77 1726
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- US $3.00 / kg
- 2025-05-26
- CAS:163451-81-8
- Min. Order: 1kg
- Purity: 0.99
- Supply Ability: 10000
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163451-81-8
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