| | 1094451-90-7 Basic information More.. |
| Product Name: | UCM05 | | Synonyms: | UCM05;G 28UCM;3-(3,4,5-Trihydroxybenzoyloxy)naphthalen-1-yl 3,4,5-trihydroxybenzoate;Benzoic acid, 3,4,5-trihydroxy-, 1,1'-(1,3-naphthalenediyl) ester;UCM05(G 28UCM) | | CAS: | 1094451-90-7 | | MF: | C24H16O10 | | MW: | 464.38 | | EINECS: | | | Mol File: | 1094451-90-7.mol |  |
Use
UCM05 is an inhibitor of fatty acid synthase that strongly suppresses the growth of human breast cancer cell lines (IC50 = 21 μM for SK-BR-3 cells). It does not alter carnitine palmitoyltransferase 1 activity or induce weight loss in mice. UCM05 can reduce cleavage of poly(ADP-ribose) polymerase, phosphorylation of HER2, Akt, and ERK1/2, and growth of established xenografts in vivo. UCM05 also blocks the GTP-binding site of the cell division protein FtsZ from Bacillus, preventing bacterial division.[Cayman Chemical]
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1094451-90-7
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