| | 80863-62-3 Basic information More.. |
| Product Name: | Alitame | | Synonyms: | (S)-3-amino-4-(((R)-1-amino-1-oxopropan-2-yl)(2,2,4,4-tetramethylthietan-3-yl)amino)-4-oxobutanoic acid;(S)-3-Amino-4-oxo-4-(((R)-1-oxo-1-((2,2,4,4-tetramethylthietan-3-yl)amino)propan-2-yl)amino)bu;(S)-3-((R)-1-(2,2,4,4-TETRAMETHYLTHIETAN-3-YLCARBAMOYL)ETHYLCARBAMOYL)-3-AMINOPROPANOIC ACID;Alitame;l-alpha-aspartyl-n-(2,2,4,4-tetramethyl-3-thietanyl)-d-alaninamide;l-α-aspartyl-N-(2，2，4，4-tetramethyl-3-thietanyl)-D-alaninamide;CP 54802;(S)-3-AMino-4-oxo-4-(((R)-1-oxo-1-((2,2,4,4-tetraMethylthietan-3-yl)aMino)propan-2-yl)aMino)butanoic acid | | CAS: | 80863-62-3 | | MF: | C14H25N3O4S | | MW: | 331.43 | | EINECS: | 1312995-182-4 | | Mol File: | 80863-62-3.mol |  |
Use
Alitame may be synthesized by a number of routes.For example,
3-(D-alaninamido)-2,2,4,4-tetramethylthietane is dissolved in water
and L-aspartic acid N-thiocarboxyanhydride is then added in
portions with vigorous stirring, maintaining the pH of 8.5–9.5.
The pH is then adjusted to 5.5 and p-toluenesulfonic acid
monohydrate is added over a period of one hour. The precipitated
crystalline p-toluenesulfonate salt is collected by filtration. To
obtain alitame from its salt, a mixture of Amberlite LA-1 (liquid
anion exchange resin), dichloromethane, deionized water, and the
salt is stirred for one hour, resulting in two clear layers. The aqueous
layer is treated with carbon, clarified by filtration, and cooled to
crystallize alitame.
Alternatively, tetramethylthietane amine is condensed with anNprotected
form of D-alanine to give alanyl amide. This is then
coupled to a protected analogue of L-aspartic acid to give a crude
form of alitame. The crude product is then purified.
- Alitame
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- US $10.00 / kg
- 2024-04-25
- CAS:80863-62-3
- Min. Order: 1kg
- Purity: 99.7%
- Supply Ability: 200000kg
- Alitame
-
- US $0.00-0.00 / kg
- 2023-08-02
- CAS:80863-62-3
- Min. Order: 1kg
- Purity: 0.99
- Supply Ability: 50000kg
- Alitame
-
- US $0.00 / KG
- 2023-01-31
- CAS:80863-62-3
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 50000KG/month
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80863-62-3
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