| | 131436-22-1 Basic information More.. |
| Product Name: | Cercosporamide | | Synonyms: | Cercosporamide;(R)-8-Acetyl-9,9a-dihydro-1,3,7-trihydroxy-9aβ-methyl-9-oxodibenzofuran-4-carboxamide;4-Dibenzofurancarboxamide;Cercosporamide from Cercosporidium henningsii;(9aS)-8-Acetyl-9,9a-dihydro-1,3,7-trihydroxy-9a-methyl-9-oxo-4-dibenzofurancaboxamide;(-)-CERCOSPORAMIDE;Cercosporamide
((-)-Cercosporamide);4-Dibenzofurancarboxamide, 8-acetyl-9,9a-dihydro-1,3,7-trihydroxy-9a-methyl-9-oxo-, (9aS)- | | CAS: | 131436-22-1 | | MF: | C16H13NO7 | | MW: | 331.28 | | EINECS: | | | Mol File: | 131436-22-1.mol |  |
Use
Cercosporamide is a natural antifungal phytotoxin isolated from the Cercosporidium fungus, which infects the leaves of cassava plants. Its antifungal effect results from its selective and potent inhibition of fungal PKC-like 1 kinases (Pkc1), which are central to cell wall integrity (IC50 = 25 nM for Candida Pkc1). Cercosporamide less effectively inhibits human PKC isoforms PKCα, β, and γ (IC50s = 1.02, 0.35, and 5.8 μM, respectively), an action linked to lowering of plasma glucose in hyperglycemic mice. However, it potently inhibits MAPK-interacting kinases Mnk1 and Mnk2 (IC50 = 115 and 11 nM, respectively), reducing protein translation in cancer cells. Cercosporamide is orally bioavailable.
- Cercosporamide
-
- $592.00
- 2026-07-14
- CAS:131436-22-1
- Purity:
- Supply Ability: 10g
- Cercosporamide
-
- $1.00
- 2020-01-19
- CAS:131436-22-1
- Min. Order: 1KG
- Purity: 99.0%
- Supply Ability: 100kg
|
|
131436-22-1
Recommend
Suppliers |
|
|
Recommend You Select Member Companies |
|
|