| | 843663-66-1 Basic information More.. |
| Product Name: | TMC-207 | | Synonyms: | TMC-207;R 207910;Bedaquiline(R 207910,TMC 207);Bedaquiline (TMC-207);(αS,βR)-Bedaquiline;bedaquinline;(1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(methylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol;Bedaquiline D6 | | CAS: | 843663-66-1 | | MF: | C32H31BrN2O2 | | MW: | 555.5 | | EINECS: | 1308068-626-2 | | Mol File: | 843663-66-1.mol |  |
Use
Bedaquiline (also known as TMC207 and R207910) is a diarylquinoline that was discovered from a high-throughput, whole-cell screening strategy with Mycobacterium smegmatis used as a surrogate for M. tuberculosis. Bedaquiline is a single enantiomer of an initial screening hit. Bedaquiline has potent and selective activity against mycobacteria, and is active against both drug-sensitive and drug-resistant M. tuberculosis. The mechanism of action of bedaquiline is unique amongst anti-TB drugs and involves inhibition of mycobacterial ATP synthase; it is not active against human ATP synthase. Bedaquiline has in vivo activity in numerous preclinical models of TB infection, alone and in combination with other anti-TB agents, and has bactericidal activity in established TB infection models.
- TMC-207
-
- US $32.00-1.30 / KG
- 2024-04-15
- CAS:843663-66-1
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
- Bedaquiline
-
- US $0.00 / g
- 2024-03-12
- CAS:843663-66-1
- Min. Order: 1g
- Purity: 98% HPLC
- Supply Ability: 1kg
- Bedaquiline
-
- US $200.00 / kg
- 2023-06-26
- CAS:843663-66-1
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 1000kg/Months
|
|
843663-66-1
Recommend Suppliers |
|