| | 1374640-70-6 Basic information More.. |
| Product Name: | CO-1686 | | Synonyms: | CO-1686;AVL-301;CNX-419;CO-1686 (AVL-301);CO-1686/CO1686;N-[3-[[2-[[4-(4-Acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide;Clovis CO-1686;CO-1686(free base) | | CAS: | 1374640-70-6 | | MF: | C27H28F3N7O3 | | MW: | 555.55 | | EINECS: | | | Mol File: | 1374640-70-6.mol |  |
Use
CO-1686 inhibited the p-EGFR in EGFR-expressing cells with an IC50 ranging from 62 to 187 nM while inhibiting EGFR phosphorylation. In three WT EGFR-expressing cells, the IC50 is larger than 2,000 nM. CO-1686 can selectively inhibit the growth of mutant EGFR expressing NSCLC cells with a GI50 ranging from 7 to 32 nM while inducing apoptosis. The CO-1686-resistant NSCLC cell line exhibited a signal for epithelial-mesenchymal transition and increased susceptibility to AKT inhibitors.
- CO-1686
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- US $1.00 / KG
- 2019-07-06
- CAS:1374640-70-6
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 1000KG
- CO-1686
-
- US $7.00 / KG
- 2019-07-06
- CAS: 1374640-70-6
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 1000KG
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1374640-70-6
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