| | 129580-63-8 Basic information More.. |
| Product Name: | Satraplatin | | Synonyms: | bis(acetato-o)amminedichloro(cyclohexanamine)-pt;platinum (lv) cis-dichloro-trans-bis(acetato-o)ammine(cyclohexanamine);SATRAPLATIN;JM 216;Bis-acetatoamminedichlorocyclohexylamine platinum(iv);C081294;Platinum, bis(acetato-o)amminedichloro(cyclohexanamine)-, (oc-6-43)-;Satraplatin(JM216) | | CAS: | 129580-63-8 | | MF: | C10H20Cl2N2O4Pt | | MW: | 498.26 | | EINECS: | | | Mol File: | 129580-63-8.mol |  |
Use
Satraplatin (JM216, cis,trans,cis-[PtCl2(OAc)2(NH3)(C6H5NH2)]) is a Pt(IV) or Pt4+ complex, which is
active by oral administration, as it is more hydrophobic than cisplatin. This form of administration is very
attractive because of the convenience and freedom it provides to the patient. Satraplatin also has a milder toxicity
profile and is shows no cross-resistance with cisplatin. Satraplatin in combination with prednisone has
completed phase III clinical trials against hormone-refractory prostate cancer. The results were very encouraging,
but the overall survival rate did not improve significantly enough. As a result, the fast-track approval
of the FDA was not granted.Structurally, satraplatin consists of a Pt(IV) centre, which is coordinated by six ligands forming a close to octahedral geometry. In general, octahedral Pt(IV) complexes (low-spin d6) are much more kinetically inert than square planar Pt(II) complexes.
- Satraplatin
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- US $80.00 / kg
- 2023-03-25
- CAS:129580-63-8
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 20 tons
- Satraplatin
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- US $0.00 / g
- 2022-12-30
- CAS:129580-63-8
- Min. Order: 10g
- Purity: 98%-102%
- Supply Ability: 100g
- Satraplatin
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- US $7.00 / KG
- 2019-07-06
- CAS:129580-63-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 200KG
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129580-63-8
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