| | 41340-25-4 Basic information More.. |
| Product Name: | Etodolac | | Synonyms: | (R)-2-(1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid;22α-Hydroxyerythrodiol Solution, 100ppm;Etodolac Imp.(EP);Etodolac impurity;1,8-DIETHYL-1,3,4,9-TETRAHYDRO-PYRANO[3,4-B]INDOLE-1-ACETIC ACID;1,3,4,9-tetrahydro-1,8-diethylpyrano(3,4-b)indole-1-aceticacid;4-b)indole-1-aceticacid,1,3,4,9-tetrahydro-1,8-diethyl-pyrano(;4-b]indole-1-aceticacid,1,8-diethyl-1,3,4,9-tetrahydro-pyrano[ | | CAS: | 41340-25-4 | | MF: | C17H21NO3 | | MW: | 287.35 | | EINECS: | 629-689-1 | | Mol File: | 41340-25-4.mol |  |
Use
Etodolac (Lodine, Ultradol), a chiral, COX-2 selectiveNSAID drug that is marketed as a racemate, possesses an indolering as the aryl portion of this group of NSAID drugs.It shares many similar properties of this group and is indicatedfor short- and long-term management of pain and OA.Similar to ketorolac, etodolac exhibits several uniqueenantioselective pharmacokinetic properties. For example,the “inactive” (R)-enantiomer has approximately a 10-foldhigher plasma concentration than the active (S)-enantiomer.Furthermore, the active (S)-enantiomer is less protein boundthan its (R)-enantiomer and therefore has a very large volumeof distribution. It is well absorbed with an elimination halflifeof 6 to 8 hours. Etodolac is extensively metabolized intothree major inactive metabolites, 6-hydroxy etodolac (via aromatichydroxylation), 7-hydroxy-etodolac (via aromatic hydroxylation),and 8-(1'-hydroxylethyl) etodolac (via benzylichydroxylation), which are eliminated as the correspondingether glucuronides. Its unstable, acyl glucuronide, however,is subject to enterohepatic circulation and reactivation tothe parent drug, similar to other NSAIDS in this class.
- Etodolac
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- US $88.00 / KG
- 2024-01-18
- CAS:41340-25-4
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 330T
- Etodolac
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- US $1.90 / KG
- 2023-03-06
- CAS:41340-25-4
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 ton
- Etodolac
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- US $0.00 / KG
- 2023-01-31
- CAS:41340-25-4
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 50000KG/month
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41340-25-4
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