| | 343306-79-6 Basic information More.. |
| Product Name: | Sugammadex sodium | | Synonyms: | ORG-25969/SugaMMadex;Sugammadex IMP;US-DMF No.: 033904
ASMF filed;6A,6B,6C,6D,6E,6F,6G,6H-Octakis-S-(2-carboxyethyl)-6A,6B,6C,...;Sugammadex sodium (Org-25969);6 Sugammadex Sodium;Glucose-sodium;Sulgeng glucose sodium | | CAS: | 343306-79-6 | | MF: | C72H104Na8O48S8 | | MW: | 2177.97 | | EINECS: | 200-838-9 | | Mol File: | 343306-79-6.mol |  |
Use
To facilitate tracheal intubation, mechanical ventilation, and surgical
access, NMB agents are frequently used as non-anesthetic adjuncts in
surgical procedures.
Sugammadex is able to function as a pharmacologic sink of rocuronium and vecuronium, another non-depolarizing
neuromuscular blocker, without the cardiovascular adverse effects
experienced with reversal agents that directly interact with the
cholinergic system. The γ-cyclodextrin has been designed to enhance
binding of the guest by incorporating acidic side chains to promote an
electrostatic interaction with the positive nitrogen of the blocker. Starting
with γ-cyclodextrin, these side chains are readily installed by first
halogenating with iodine or bromine to provide a handle for nucleophilic
displacement with either 3-mercaptopropionic acid in the presence of
sodium hydride or with 3-mercaptopropionic acid methyl ester
and cesium carbonate. The latter requires hydrolysis with sodium
hydroxide to generate sugammadex sodium.
- Sugammadex sodium
-
- US $0.00-0.00 / KG
- 2024-04-22
- CAS:343306-79-6
- Min. Order: 5KG
- Purity: 0.99
- Supply Ability: 50MT/month
- Sugammadex sodium
-
- US $0.00 / KG
- 2024-04-22
- CAS:343306-79-6
- Min. Order: 2KG
- Purity: 99% up, High Density
- Supply Ability: 20 tons
- Sugammadex sodium
-
- US $0.00 / KG
- 2024-03-28
- CAS:343306-79-6
- Min. Order: 25KG
- Purity: 98%
- Supply Ability: Inquiry
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343306-79-6
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