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Product Name:Dutasteride
Synonyms:(1S,2R,7R,10S,11S,14S,15S)-N-[2,5-bis(trifluoroMethyl)phenyl]-2,15-diMethyl-5-oxo-6-azatetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-3-ene-14-carboxaMide;(4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-[2,5-Bis(trifluoroMethyl)phenyl]-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-diMethyl-2-oxo-1H-Indeno[5,4-f]quinoline-7-carboxaMide;(5α,17β)-;(4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-[2,5-Bis(trifluoroMethyl)phenyl]-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-diMethyl-2-oxo-1H-indeno[5,4-f]quinoline-7-carboxaMide-13C6;6β-Hydroxy Dutasteride;4-Azaandrost-1-ene-17-carboxaMide, N-[2,5-bis(trifluoroMethyl)phenyl]-3-oxo-, (5a,17b)-;Avolve;Dutasteride API
CAS:164656-23-9
MF:C27H30F6N2O2
MW:528.53
EINECS:638-758-5
Mol File:164656-23-9.mol
164656-23-9

Use

Dutasteride was launched for the symptomatic treatment of benign prostatic hyperplasia. Dutasteride can be prepared from 3-oxo-4-androstene-17β-carboxylic acid by several ways in 6 or 8 steps. Dutasteride is a dual inhibitor of type 1 and 2 isoforms of 5α-reductase unlike finasteride, the first marketed 5α-reductase inhibitor, which only acts on type 2 isozyme. Dutasteride is a 3-fold greater inhibitor of type-2 5α-reductase than finasteride in men and has greater effect on the type-l than on type-2 isozyme. In animal models,dutasteride exhibited superior efficacy and pharmacokinetics compared to finasteride.

Dutasteride manufacturers

  • Dutasteride
  • US $7.30-5.80 / g
  • 2024-04-27
  • CAS:164656-23-9
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 100kg
  • Dutasteride
  • US $3.00-2.00 / grams
  • 2024-04-26
  • CAS:164656-23-9
  • Min. Order: 1grams
  • Purity: 99%
  • Supply Ability: 100tons
  • Dutasteride
  • US $100.00 / kg
  • 2024-04-25
  • CAS:164656-23-9
  • Min. Order: 1kg
  • Purity: 99.9%
  • Supply Ability: 20tons
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