| 768-94-5 Basic information More.. |
Product Name: | Amantadine | Synonyms: | 1-ADAMANTAMINE;1-Adamantanamin;1-Amantadine;1-Aminoadamatane;1-aminodiamantane;1-aminotricyclo(3.3.1.1(sup3,7))decane;1-Aminotricyclo(3.3.1.13,7)decane;1-aminotricyclo[3.3.1.1(sup3,7)]decane | CAS: | 768-94-5 | MF: | C10H17N | MW: | 151.25 | EINECS: | 212-201-2 | Mol File: | 768-94-5.mol | |
Use
Amantadine has been used for years as a treatment for Parkinson disease. The adamantanamines have twomechanisms in common:they inhibit an early step in viralreplication, most likely viral uncoating,and in somestrains, they affect a later step that probably involves viral assembly,possibly by interfering with hemagglutinin processing.The main biochemical locus of action is the influenzatype A virus M2 protein, which is an integral membrane proteinthat functions as an ion channel. The M2 channel is a protontransport system. By interfering with the function of theM2 protein, the adamantanamines inhibit acid-mediated dissociationof the ribonucleoprotein complex early in replication.They also interfere with transmembrane proton pumping,maintaining a high intracellular proton concentrationrelative to the extracellular concentration and enhancingacidic pH-induced conformational changes in the hemagglutininduring its intracellular transport at a later stage. The conformationalchanges in hemagglutinin prevent transfer of thenascent virus particles to the cell membrane for exocytosis.
- Amantadine
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- US $50.00-45.00 / kg
- 2024-03-28
- CAS:768-94-5
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 8000kg
- Amantadine
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- US $9.90-9.90 / g
- 2024-01-20
- CAS:768-94-5
- Min. Order: 5g
- Purity: 99.99%HPLC.USP42——Powder、Oil、Pills、Capsules、Tablets,Customiz
- Supply Ability: 100kg
- Amantadine
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- US $25.00 / kg
- 2023-08-22
- CAS:768-94-5
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 100tons
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768-94-5
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