768-94-5 Basic information More..
Product Name:Amantadine
Synonyms:1-ADAMANTAMINE;1-Adamantanamin;1-Amantadine;1-Aminoadamatane;1-aminodiamantane;1-aminotricyclo(3.3.1.1(sup3,7))decane;1-Aminotricyclo(3.3.1.13,7)decane;1-aminotricyclo[3.3.1.1(sup3,7)]decane
CAS:768-94-5
MF:C10H17N
MW:151.25
EINECS:212-201-2
Mol File:768-94-5.mol
768-94-5

Use

Amantadine has been used for years as a treatment for Parkinson disease. The adamantanamines have twomechanisms in common:they inhibit an early step in viralreplication, most likely viral uncoating,and in somestrains, they affect a later step that probably involves viral assembly,possibly by interfering with hemagglutinin processing.The main biochemical locus of action is the influenzatype A virus M2 protein, which is an integral membrane proteinthat functions as an ion channel. The M2 channel is a protontransport system. By interfering with the function of theM2 protein, the adamantanamines inhibit acid-mediated dissociationof the ribonucleoprotein complex early in replication.They also interfere with transmembrane proton pumping,maintaining a high intracellular proton concentrationrelative to the extracellular concentration and enhancingacidic pH-induced conformational changes in the hemagglutininduring its intracellular transport at a later stage. The conformationalchanges in hemagglutinin prevent transfer of thenascent virus particles to the cell membrane for exocytosis.

Amantadine manufacturers

  • Amantadine
  • US $50.00-45.00 / kg
  • 2024-03-28
  • CAS:768-94-5
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 8000kg
  • Amantadine
  • US $9.90-9.90 / g
  • 2024-01-20
  • CAS:768-94-5
  • Min. Order: 5g
  • Purity: 99.99%HPLC.USP42——Powder、Oil、Pills、Capsules、Tablets,Customiz
  • Supply Ability: 100kg
  • Amantadine
  • US $25.00 / kg
  • 2023-08-22
  • CAS:768-94-5
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 100tons
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