| 113665-84-2 Basic information More.. |
Product Name: | Clopidogrel | Synonyms: | CLOPIDOGREL;ClopidogrelHydrobromide;ClopidogrelHydrogenSulfateBase;ClopidogrelHcl;Methyl (+)-(S)-α-(o-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetate;(S)- α-(2-Chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic acidmethyl ester;Clopidogrel Pellets;Methyl (2S)-2-(2-chlorophenyl)-2-{4H,5H,6H,7H-thieno[3,2-c]pyridin-5-yl}acetate | CAS: | 113665-84-2 | MF: | C16H16ClNO2S | MW: | 321.82 | EINECS: | 601-269-2 | Mol File: | 113665-84-2.mol | |
Use
Clopidogrel was launched in the US as a potent inhibitor of platelet
aggregation for the preventive management of secondary ischemic events,
including MI, stroke and vascular deaths. Clopidogrel can be synthesized in 4
steps (including an optical resolution to the S active enantiomer) from 2-(2-
ch1orophenyl)-glycine, the key step being the cyclization to thienopyridine with
formaldehyde and acetic acid. Clopidogrel belongs to the original chemical class
of Ticlopidine, but shows fewer side effects (in particular, bone-marrowsuppressing
effects) at the dosage generally used. Like Ticlopidine, it is an
Adenosine diphosphate (ADP) antagonist acting at the purinergic P2y receptor.
In in vivo experiments with rabbits, Clopidogrel shows a maximal antiaggregant
effect at 20mg/kg po, reducing adhesion of platelets to the vascular
subendothelium ; moreover, it reduces myointimal thickening occuring after
endothelial injury of rat carotid artery. Clopigrel does not affect platelet
aggregation in vitro ; actually, its in vivo activity is highly dependent on hepatic
metabolism. The results of a CAPRIE trial (Clopidogrel versus Aspirin in patients
at risk of ischemic events) demonstrated that Clopidogrel was well tolerated and
more effective than aspirin.
- Clopidogrel
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- US $990.00-800.00 / ton
- 2024-09-24
- CAS:113665-84-2
- Min. Order: 1ton
- Purity: 99%
- Supply Ability: 5000
- Clopidogrel
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- US $0.00-0.00 / Kg
- 2024-09-23
- CAS:113665-84-2
- Min. Order: 1Kg
- Purity: 99.9%
- Supply Ability: 200tons
- Clopidogrel
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- US $0.00-0.00 / Kg/Drum
- 2024-09-18
- CAS:113665-84-2
- Min. Order: 1KG
- Purity: 98%min
- Supply Ability: 1000kg
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113665-84-2
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