| | 4291-63-8 Basic information More.. |
| Product Name: | Cladribine | | Synonyms: | 2-chlorodeoxyadenosine;Biodribin;Cladarabine;Jk 6251;NSC 105014;(2R,3S,5R)-5-(6-aMino-2-chloro-9H-purin-9-yl)-2-(hydroxyMethyl)oxolan-3-ol;Cladribine API;2-Chloro-2'-deoxyadenosine
2-Chloro-9-(2-deoxy-beta-D-arabinofuranosyl)adenine
CdA | | CAS: | 4291-63-8 | | MF: | C10H12ClN5O3 | | MW: | 285.69 | | EINECS: | 636-978-6 | | Mol File: | 4291-63-8.mol |  |
Use
Cladribine, an adenosine deaminase inhibitor, was introduced in the United States as a single intravenous treatment for hairy cell leukemia. The incorporation of a chlorine atom at the 2-position of deoxyadenosine renders cladribine more resistant to enzymatic attack by adenosine deaminase, resulting in a more prolonged cytotoxic effect. Cladribine efficiently crosses lymphocyte and monocyte cell membranes and is metabolized in cells to the biologically active triphosphate, which inhibits DNA synthesis. While most antineoplastic drugs are active primarily against dividing cells, cladribine destroys both resting and proliferating cells. Its potential uses in the treatment of autoimmune hemolytic anemia, multiple sclerosis, chronic lymphocytic leukemia and various lymphomas have also been evaluated.
- Cladribine
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- US $10.00-2.00 / KG
- 2024-04-28
- CAS:4291-63-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
- Cladribine
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- US $0.00 / kg
- 2024-04-15
- CAS:4291-63-8
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 20tons
- Cladribine
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- US $0.00 / KG
- 2023-10-16
- CAS:4291-63-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 50000KG/month
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4291-63-8
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