| | 61-75-6 Basic information More.. |
| Product Name: | BRETYLIUM TOSYLATE | | Synonyms: | (o-bromobenzyl)ethyldimethyl-ammoniup-toluenesulfonate;2-bromo-n-ethyl-n,n-dimethylbenzenemethanaminium4-methylbenzenesulfonate;2-bromo-n-ethyl-n,n-dimethyl-benzenemethanaminiusaltwith4-methylbenzen;darentin;dimethylethyl-o-bromobenzylammonium-p-toluenesulphonate;esulfonicacid;n-ethyl-n-o-bromobenzyl-n,n-dimethylammoniumtosylate;ornid | | CAS: | 61-75-6 | | MF: | C18H24BrNO3S | | MW: | 414.36 | | EINECS: | 200-516-8 | | Mol File: | 61-75-6.mol |  |
Use
Bretylium tosylate, (o-bromobenzyl)ethyl dimethylammonium p-toluenesulfonate(Bretylol), is an extremely bitter, white, crystalline powder.The chemical is freely soluble in water and alcohol.Bretylium tosylate is an adrenergic neuronal-blockingagent that accumulates selectively in the neurons anddisplaces norepinephrine. Because of this property,bretylium was used initially, under the trade name ofDarenthin, as an antihypertensive agent. It caused posturaldecrease in arterial pressure. This use was discontinuedbecause of the rapid development of tolerance, erratic oralabsorption of the quaternary ammonium compound, andpersistent pain in the parotid gland on prolonged therapy.
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61-75-6
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