| | 1018899-04-1 Basic information More.. |
| Product Name: | LX-4211 | | Synonyms: | LX-4211;(2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(Methylthio)tetrahydro-2H-pyran-3,4,5-triol;(5S)-Methyl 5-C-[4-chloro-3-[(4-ethoxyphenyl)Methyl]phenyl]-1-thio-beta-L-xylopyranoside;LX4211/LX-4211;LP 802034;LX4211 - L10525;LX-4211 (sotagliflozin);LX-4211, >=98% | | CAS: | 1018899-04-1 | | MF: | C21H25ClO5S | | MW: | 424.94 | | EINECS: | | | Mol File: | 1018899-04-1.mol |  |
Use
Sotagliflozin is a dual SGLT-1/SGLT-2 inhibitor which is currently under development by Lexicon Pharmaceuticals (phase III). It follows a similar strategy to ertugliflozin, i.e. aryl addition on an acyclic precursor. The synthesis starts from L-xylose 53, and the aryl moiety (same aryl moiety as for dapagliflozin) is introduced on an amide derivative (morpholine amide 54) via Grignard addition. A subsequent transformation leads to the sotagliflozin (Scheme 10). The overall yield of the synthesis is around 30%.
Sotagliflozin synthesis
Sotagliflozin is a dual SGLT-1/SGLT-2 inhibitor which is currently under development by Lexicon Pharmaceuticals (phase III). It follows a similar strategy to ertugliflozin, i.e. aryl addition on an acyclic precursor. The synthesis starts from L-xylose 53, and the aryl moiety (same aryl moiety as for dapagliflozin) is introduced on an amide derivative (morpholine amide 54) via Grignard addition. A subsequent transformation leads to the sotagliflozin (Scheme 10). The overall yield of the synthesis is around 30%.
Sotagliflozin synthesis
- Sotagliflozin;LX-4211
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- US $0.00-0.00 / kg
- 2024-03-15
- CAS:1018899-04-1
- Min. Order: 1kg
- Purity: 99
- Supply Ability: 500kg
- Sotagliflozin; LX-4211
-
- US $5500.00 / g
- 2023-11-01
- CAS:1018899-04-1
- Min. Order: 1g
- Purity: 99.0%min， single impurity：0.5%min
- Supply Ability: 500kg
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1018899-04-1
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Product Name:(2S,3R,4R,5S,6R)-2-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-6-methylsulfanyloxane-3,4,5-triol
CAS:1018899-04-1
Purity:98% Package:1g,5g,25g,500g,1kg |
| CB Index: |
58 |
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