| | 22131-79-9 Basic information More.. |
| Product Name: | ALCLOFENAC | | Synonyms: | 4-(Allyloxy)-3-chlorobenzeneacetic acid;2-(3-chloro-4-prop-2-enoxyphenyl)acetic acid;2-(3-chloro-4-prop-2-enoxy-phenyl)ethanoic acid;2-(4-allyloxy-3-chloro-phenyl)acetic acid;3-chloro-4-(2-propenyloxy)-benzeneaceticaci;3-chloro-4-(2-propenyloxy)benzeneaceticacid;4-allyloxy-3-chlorophenyl-aceticaci;Acetic acid, [4-(allyloxy)-3-chlorophenyl]- | | CAS: | 22131-79-9 | | MF: | C11H11ClO3 | | MW: | 226.66 | | EINECS: | 244-795-4 | | Mol File: | 22131-79-9.mol |  |
Use
Alclofenac, a phenylacetic acid derivative with analgesic,
antipyretic and antiinflammatory activity, was introduced in 1972 for the treatment
of rheumatic disorders. In the late 1970s its use was associated with a high
incidence of adverse effects, mainly skin rashes, and a urinary metabolite was reported to have mutagenic activity (positive Ames test). This resulted in the
withdrawal of the drug, in some cases voluntarily, from several countries. In others
registration has been refused. The reported mutagenic potential has been
questioned by some investigators and the drug remains on the market in at least
three countries with highly evolved regulatory authorities.
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22131-79-9
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