| | 113852-37-2 Basic information More.. |
| Product Name: | Cidofovir | | Synonyms: | Cidofovir (Vistide);(S)-[1-(4-AMino-2-oxo-pyriMidin-1(2H)-yl)-3-hydroxy-propan-2-yl]oxyMethylphosphonic acid;({[(S)-1-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3-hydroxypropan-2-yl]oxy}methyl)phosphonic acid;Cidofovir(GS-504);(S)-(3-(4-amino-2-oxopyrimidin-1(2H)-yl)-1-hydroxypropan-2-yloxy)methylphosphonic acid;(S)-1-[3-HYDROXY-2-(PHOSPHONYL-METHOXY)PROPYL]-CYTOSINE;(S)-1-(3-HYDROXY-2-PHOSPHONYLMETHOXYPROYPL)CYTOSINE;[1-(4-amino-2-oxo-pyrimidin-1-yl)-3-hydroxy-propan-2-yl]oxymethylphosphonic acid | | CAS: | 113852-37-2 | | MF: | C8H14N3O6P | | MW: | 279.19 | | EINECS: | 638-807-0 | | Mol File: | 113852-37-2.mol |  |
Use
Cidofovir, (S)-3-hydroxy-2-phosphonomethoxypropyl cytosine(HPMPC, Vistide), is an acyclonucleotide analog thatpossesses broad-spectrum activity against several DNAviruses. Unlike other nucleotide analogs that are activated tonucleoside phosphates, Cidofovir is a phosphonic acid derivative.The phosphonic acid is not hydrolyzed by phosphatasesin vivo but is phosphorylated by cellular kinases to yield adiphosphate. The diphosphate acts as an antimetabolite to deoxycytosinetriphosphate (dCTP). Cidofovir diphosphate is acompetitive inhibitor of viral DNA polymerase and can beincorporated into the growing viral DNA strand, causingDNA chain termination.Cidofovir possesses a high therapeutic index against CMVand has been approved for treating CMV retinitis in patientswith AIDS. Cidofovir is administered by slow, constant intravenousinfusion in a dose of 5 mg/kg over a 1-hour periodonce a week for 2 weeks. This treatment is followed by amaintenance dose every 2 weeks.
- Cidofovir
-
- US $0.00-0.00 / kg
- 2022-09-30
- CAS:113852-37-2
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1Ton
- cidofovir
-
- US $10.00 / KG
- 2021-08-12
- CAS:113852-37-2
- Min. Order: 1g
- Purity: 99
- Supply Ability: 100kg/kg
- Cidofovir USP/EP/BP
-
- US $1.10 / g
- 2021-07-16
- CAS:113852-37-2
- Min. Order: 1g
- Purity: 99.9%
- Supply Ability: 100 Tons Min
|
|
113852-37-2
Recommend Suppliers |
|