| | 11029-61-1 Basic information More.. |
| Product Name: | GRAMICIDIN A | | Synonyms: | OHC-NH-VAL-GLY-ALA-D-LEU-ALA-D-VAL-VAL-D-VAL-TRP-D-LEU-TRP-D-LEU-TRP-D-LEU-TRP-CONCH2CH2OH;OHC-NH-VAL-GLY-ALA-D-LEU-ALA-D-VAL-VAL-D-VAL-TRP-D-LEU-TRP-D-LEU-TRP-D-LEU-TRP-D-LEU-TRP-CONHCH2CH2OH;HCO-VAL-GLY-ALA-D-LEU-ALA-D-VAL-VAL-D-VAL-TRP-D-LEU-TRP-D-LEU-TRP-D-LEU-NHCH2CH2OH;HCO-VAL-GLY-ALA-D-LEU-ALA-D-VAL-VAL-D-VAL-TRP-D-LEU-TRP-D-LEU-TRP-D-LEU-TRP-NHCH2CH2OH;HCO-X-GLY-L-ALA-D-LEU-L-ALA-D-VAL-L-VAL-D-VAL-L-TRP-D-LEU-L-TRP-D-LEU-L-TRP-D-LEU-L-TRP-NHCH2CH2OH;GRAMICIDIN A;GRAMICIDIN A, BACILLUS BREVIS;GRIMICIDIN A | | CAS: | 11029-61-1 | | MF: | C99H140N20O17 | | MW: | 1882.29 | | EINECS: | 234-259-8 | | Mol File: | 11029-61-1.mol |  |
Use
Purify gramicidin A by countercurrent distribution from *C6H6/CHCl3, MeOH/H2O (15:15:23:7) with 5000 tubes. Fractions are examined by UV (280nm) of small aliquots. Separation from gramicidin C and other material occurred after 999 transfers. [Gross & Witkop Biochemistry 4 2495 1965, Bauer et al. Biochemistry 11 3266 1972.] Purify it finally by recrystallisation from EtOH/H2O and dry it at 100o/10-2mm over KOH. It forms platelets m 229-230o. It is almost insoluble in H2O (0.6%) but soluble in lower alcohols, dry Me2CO, dioxane, acetic acid and pyridine. The commercial material is more difficult to crystallise than the synthetic compound. [Sarges & Witkop J Am Chem Soc 86 1861 1964, 87 2011, 2020 1965.] It has characteristic [] D20 +27.3o (c 1.3, MeOH) and UV max at 282nm ( 22,100). The N-carbamoyldeformyl gramicidine A precipitates from EtOAc/pet ether (b 40-60o). [Beilstein 26 III/IV 4273.]
- GRAMICIDIN A USP/EP/BP
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- US $1.10 / g
- 2021-07-20
- CAS:11029-61-1
- Min. Order: 1g
- Purity: 99.9%
- Supply Ability: 100 Tons Min
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11029-61-1
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