72-19-5 Basic information More..
Product Name:L-Threonine
Synonyms:L-2-AMINO-3-HYDROXYBUTANOIC ACID;L-2-AMINO-3-HYDROXYBUTYRIC ACID;L-THR;L(-)-THREONINE;L-THREONINE;H-L-THR-OH;H-THR-OH;H-THR-OH-THREONINE
CAS:72-19-5
MF:C4H9NO3
MW:119.12
EINECS:200-774-1
Mol File:72-19-5.mol
72-19-5

Use

L-Threonine can be produced using strains of E. coli or C. glutamicum. As threonine is also an amino acid of the aspartate family, aspartate semialdehyde is a common intermediate with the biosynthesis of L-lysine. In order to optimize a high-yielding L-threonine–producing strain, the following strategy is applied: the pathway towards L-lysine is minimized by reducing the activity of dihydrodipicolinate synthase (dapA) and at the same time the pathway towards L-threonine is favored by overexpression of the genes of the threonine operon, which consists of the genes for homoserine dehydratase (thrA), homoserine kinase (thrB), and threonine synthase (thrC). As L-threonine is also a precursor for L-isoleucine, further conversion of L-threonine into L-isoleucine has to be minimized by deactivation of the threonine dehydratase gene (ilvA). In the meantime, E. coli based strains have also been developed by the application of systems biology, not only by deletion or downregulation of the competing pathways such as L-lysine, L-methionine, and L-isoleucine, but also by optimization of the supply of key precursors such as oxaloacetate. The E. coli strain has been reported to produce 82 g/L L-threonine in 48 h with a carbon yield of 39 %. A more detailed description of the development of a commercial L-threonine process has been given by Debabov. Today L-threonine is manufactured on a commercial scale of several thousand tonnes using the E. coli fermentation process.

Lastest Price from L-Threonine manufacturers

  • L-Threonine
  • US $1.50 / KG
  • 2021-10-15
  • CAS:72-19-5
  • Min. Order: 100g
  • Purity: 99%
  • Supply Ability: 500ton/Month
  • lead nitrate
  • US $2280.00 / T
  • 2021-10-14
  • CAS:72-19-5
  • Min. Order: 1KG
  • Purity: 99.99%
  • Supply Ability: 20 tons
  • L-Threonine
  • US $0.00 / KG
  • 2021-10-08
  • CAS:72-19-5
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 200kg
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