| | 703-95-7 Basic information More.. |
| Product Name: | 5-Fluoroorotic acid | | Synonyms: | 1,2,3,6-tetrahydro-2,6-dioxo-5-fluoro-4-pyrimidinecarboxylicaci;1,2,3,6-tetrahydro-2,6-dioxo-5-fluoro-4-pyrimidinecarboxylicacid;nsc31712;ro2-9945;2,6-Dihydroxy-5-fluoropyrimidine-4-carboxylic acid;5-FLUOROURACIL-4-CARBOXYLIC ACID;5' FOA;5-FLUORO-2,6-DIOXO-3H-PYRIMIDINE-4-CARBOXYLIC ACID | | CAS: | 703-95-7 | | MF: | C5H3FN2O4 | | MW: | 174.09 | | EINECS: | 211-876-0 | | Mol File: | 703-95-7.mol |  |
Use
5-FOA(5-Fluoroorotic acid ) has become a valuable tool for research in the field of molecular genetics. It has been employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5'-phosphate decarboxylase deficient. 5-FOA is coverted to 5-fluorouridine monophosphate (5-FUMP) in yeast cells, which can become incorporated into RNA or metabolized to the highly toxic 5-fluoro-2’-deoxyuridine monophosphate (5-FdUMP). 5-FdUMP is a potent inhibitor of thymidylate synthase (TS), causing the cessation of DNA synthesis. More recently, 5-FOA has been shown to possess potent antimalarial activity against both chloroquine-susceptible and chloroquine-resistant clones of Plasmodium falciparum. Studies indicate that TS is the primary target of 5-FOA in malarial parasites. The combination of 5-FOA and uracil has been effective in treating mice infected with Plasmodium yoelli. 5-FOA may also have potential in the treatment of human malarial infections when used in combination with other agents.
- 5-Fluoroorotic acid
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- US $100.00 / kg
- 2023-04-25
- CAS:703-95-7
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 100 tons
- 5-Fluoroorotic Acid
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- US $10.00 / Kg/Drum
- 2023-03-06
- CAS:703-95-7
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 10 ton
- 5-Fluoroorotic acid
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- US $15.00-10.00 / KG
- 2021-07-13
- CAS:703-95-7
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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703-95-7
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