202475-60-3 Basic information More..
Product Name:JAK3 INHIBITOR I
Synonyms:4-(4'-HYDROXYPHENYL)AMINO-6,7-DIMETHOXYQUINAZOLINE;JAK3 INHIBITOR I;WHI-P131;Janex 1;A JAK3 inhibitor WHI-P131;4-(6,7-dimethoxyquinazolin-4-ylamino)phenol;WHI-P131(Janex 1);JANEX-1;WHI-P131
CAS:202475-60-3
MF:C16H15N3O3
MW:297.31
EINECS:
Mol File:202475-60-3.mol
202475-60-3

Use

Janex 1 is a Janus tyrosine kinase 3 (JAK3) inhibitor. Inhibition of JAK3 has been shown to exhibit protective action against the development of T1D in non-obese diabetic (NOD) mice. Janex 1 has been shown to suppresses proliferation of short-term cultured NOD CD4+ T cells through induction of apoptosis, while promoting survival of a particular population of long-term cultured cells. It ameliorates the expression of TNF-α-induced cell adhesion molecules and improves myocardial vascular permeability.

JAK3 INHIBITOR I manufacturers

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