163222-33-1 Basic information More..
Product Name:Ezetimibe
Synonyms:Ezetimibe-001;(3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one;SCH-58235;EzetiMib;(3R,4S)-1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone;EzitiMibeEzetiMibeC24H21F2N03;Ticagrelor and its interMediate;Ezetimibe 1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxy-propyl]-4-(4-hydroxyphenyl)-azetidin-2-one
CAS:163222-33-1
MF:C24H21F2NO3
MW:409.43
EINECS:682-606-0
Mol File:163222-33-1.mol
163222-33-1

Use

Ezetimibe is a once-daily orally active cholesterol absorption inhibitor, launched as a hypolipidemic agent. The one-step diastereo- and enantioselective formation of β-lactams starting from commercially available (3S)-hydroxy-y-lactone is the key point of the asymmetric synthesis of ezetimibe. The 2-azetidinone class was initially designed as acylcoenzyme A: cholesterol acyltransferase (ACAT) inhibitors but experimental data suggest that this compound acts in the intestinal wall to inhibit cholesterol through a novel mechanism with an as yet undiscovered target. Orally administered ezetimibe inhibited increases in plasma cholesterol in four cholesterol-fed animals species (hamster, rats, dogs and rhesus monkeys). In rats cannulated in the intestine and bile duct, [3H]-ezetimibe inhibited cholesterol absorption by more than 95%. In cholesterol-fed LDL receptor+apoE knockout mice, treatment with ezetimibe reduced atherosclerotic lesion cross sectional area by 48% in the aorta and 20% in the carotid artery. Moreover, the plasma cholesterol levels were reduced and the progression of lesions was inhibited. Ezetimibe is highly protein bound and is metabolized by the liver to its glucuronide metabolite, which represents 80-90% of circulating ezetimibe. About 90% of ezetimibe and/or the glucuronide metabolite are excreted in the feces and 10% in the urine. The parent compound and its glucuronide metabolite undergo enterohepatic recirculation; in consequence, the drug is slowly eliminated. In hypercholesterolemic patients, ezetimibe (10 mglday, 12 weeks) reduced LDL cholesterol by 18% and total cholesterol by 12%, with a similar safety profile to placebo. Co-administration of ezetimibe with statins or fenofibrate lowered LDL cholesterol levels more than either monotherapy. Ezetimibe was well tolerated and interaction studies provided evidence that ezetimibe had no significant effect on the activity of major CYP450 drug-metabolizing enzymes. Moreover, no pharmacokinetic/pharmacodynamic interactions were seen between ezetimibe and statins and others frequently administered drugs. .

Lastest Price from Ezetimibe manufacturers

  • Ezetimibe
  • US $0.00 / 公斤
  • 2020-01-08
  • CAS:163222-33-1
  • Min. Order: 1G
  • Purity: 99%min
  • Supply Ability: 20Ton
  • Cimetidine
  • US $0.00 / Kg/Drum
  • 2019-10-25
  • CAS:163222-33-1
  • Min. Order: 25Kg/Drum
  • Purity: ≥99%
  • Supply Ability: 1 tons
  • Ezetimibe
  • US $1.00 / KG
  • 2019-07-06
  • CAS:163222-33-1
  • Min. Order: 1G
  • Purity: 98%
  • Supply Ability: 100KG
Information Error Report
Your Email:
163222-33-1 Recommend Suppliers
Recommend You Select Member Companies...
Company Name: Nanjing Gold Pharmaceutical Technology Co. Ltd.      Recommend     Complaint
Tel: 025-84209270 15906146951
FAX: 025-84209270
Email: wgp@nanjing-pharmaceutical.com
Nationality: CHINA
Products Intro: Product Name:Ezetimibe
CAS:163222-33-1
Purity:99% Package:1000KG;;100KG;10KG;5KG;1KG
CB Index: 55
WebSite: en.nanjing-pharmaceutical.com
Related Information: Sales Network   Catalog(115)   User Evaluation
Company Name: Beijing Cooperate Pharmaceutical Co.,Ltd.      Recommend     Complaint
Tel: +86-10-60279497 +86(0)15646567669
FAX: +86-10-60279497
Email: sales01@cooperate-pharm.com
Nationality: CHINA
Products Intro: Product Name:Ezetimibe
CAS:163222-33-1
Purity:98% Package:100G;1KG;5KG;10KG;25KG;50KG;100KG
CB Index: 55
WebSite: www.bjcoopharm.com
Related Information: Sales Network   Catalog(1817)   User Evaluation
Company Name: Casorganics US Corp      Recommend     Complaint
Tel: +17326109938
FAX:
Email: sales@casorganics.com
Nationality: CHINA
Products Intro: Product Name:Ezetimibe
CAS:163222-33-1
Purity:99.98% Package:1KG;USD|5KG;USD|25KG;USD
CB Index: 58
WebSite: www.chemicalbook.com/ShowSupplierProductsList31338/0.htm
Related Information: Sales Network   Catalog(175)   User Evaluation
Company Name: Capot Chemical Co.,Ltd.      Recommend     Complaint
Tel: +86-571-85586718
FAX: +86-571-85864795
Email: sales@capotchem.com
Nationality: China
Products Intro: Product Name:1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxy-propyl]-4-(4-hydroxyphenyl)-azetidin-2-one
CAS:163222-33-1
Purity:98%(Min.HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
CB Index: 60
WebSite: www.capotchem.com
Related Information: Sales Network   Catalog(19923)   User Evaluation(3)
Company Name: Jinan Jianfeng Chemical Co., Ltd      Recommend     Complaint
Tel: 15562555968
FAX:
Email: info@pharmachemm.com
Nationality: CHINA
Products Intro: Product Name:Ezetimibe
CAS:163222-33-1
Purity:99% Package:5KG;1KG;25kg Remarks:pharm intermediate
CB Index: 58
WebSite: www.chemicalbook.com/ShowSupplierProductsList31185/0.htm
Related Information: Sales Network   Catalog(297)   User Evaluation
Company Name: Jinan Shengqi pharmaceutical Co,Ltd      Recommend     Complaint
Tel: 86+18663751872
FAX:
Email: christine@shengqipharm.com
Nationality: CHINA
Products Intro: Product Name:Ezetimibe
CAS:163222-33-1
Purity:99% Package:As customer's requirement
CB Index: 58
WebSite: www.shengqipharm.com
Related Information: Sales Network   Catalog(556)   User Evaluation
Company Name: Zhuozhou Wenxi import and Export Co., Ltd      Recommend     Complaint
Tel: +8613111626072
FAX: +8613111626072
Email: zzwenxi@126.com
Nationality: CHINA
Products Intro: Product Name:Ezetimibe
CAS:163222-33-1
Purity:0.99 Package:1KG;5KG;10KG;25KG;50KG
CB Index: 58
WebSite: https://www.chemicalbook.com/ShowSupplierProductsList403210/0.htm
Related Information: Sales Network   Catalog(7497)   User Evaluation
Company Name: Amadis Chemical Company Limited      Recommend     Complaint
Tel: 0086-571-89925085
FAX: 0086-571-89925065
Email: sales@amadischem.com
Nationality: China
Products Intro: Product Name:Ezetimibe
CAS:163222-33-1
Purity:0.97 Package:mgs,gs,kgs Remarks:A810456
CB Index: 58
WebSite: www.amadischem.com
Related Information: Sales Network   Catalog(132152)   User Evaluation(1)
Tag: 163222-33-1