| | 162401-32-3 Basic information More.. |
| Product Name: | Roflumilast | | Synonyms: | ROFLUMILAST;3-(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide;B 9302-107;BY 217;BYK 20869;Daxas;Roflumilast / 3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide;3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide | | CAS: | 162401-32-3 | | MF: | C17H14Cl2F2N2O3 | | MW: | 403.21 | | EINECS: | 685-382-2 | | Mol File: | 162401-32-3.mol |  |
Use
Roflumilast is taken orally and is metabolized by cytochrome oxidase P45(CYP)3A4 and CYP1A2 enzyme into N-oxide. Roflumilast N-oxides activity is only 2-3 times weaker than that of roflumilast, and it also has relatively high PDE-4 selectivity. 90% of PDE-4 inhibition in the body is achieved by roflumilast N-oxide, while the other 10% is achieved by the original drug. A daily 500ng oral dose of roflumilast for a healthy person will produce a free blood concentration of roflumilast N-oxide in 24 hours of about 1-2 nmolL-1, and its serum protein binding rate is about 97%. Smoking has little impact on roflumilasts pharmacokinetics. Roflumilast mostly affects inflammation cells related to asthma, including eosinophils, neutrophils, and mast cells. This drug can specifically affect a certain enzyme that participates in smooth muscle contraction, it can prevent cAMP decomposition, thus preventing the signal transduction for inflammatory reactions, and it is anti-inflammatory, giving it relatively good curative effects in clinically treating asthma and COPD. Roflumilast can also significantly extend the deterioration of respiratory symptoms while also dramatically increasing patients quality of life.
- Roflumilast
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- US $0.00 / KG
- 2024-03-16
- CAS:162401-32-3
- Min. Order: 100g
- Purity: 98%+
- Supply Ability: 100kg
- Roflumilast
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- US $50.00 / kg
- 2023-09-07
- CAS:162401-32-3
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 10000tons
- Roflumilast
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- US $0.00 / KG
- 2023-09-01
- CAS:162401-32-3
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 50000KG/month
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162401-32-3
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