| | 98-96-4 Basic information More.. |
| Product Name: | Pyrazinamide | | Synonyms: | PyrazinamidePyrazinamideBp/Usp/Ep;Pezetamid;Piraldina;Pirazinecarboxamide;PYRAZINAMIDE,USP;Pyrazine-2-carboxamide 97%;PYRAZINAMIDE PYRAZINE-2-CARBOXYLIC ACID AMIDE;2-(AMINOCARBONYL)-PYRAZINE(Pyrazinamide) | | CAS: | 98-96-4 | | MF: | C5H5N3O | | MW: | 123.11 | | EINECS: | 202-717-6 | | Mol File: | 98-96-4.mol |  |
Use
Pyrazinecarboxamide (PZA) occurs as a white crystalline powder that is sparingly soluble in water and slightly soluble in polar organic solvents. Its antitubercular properties were discovered as a result of an investigation of heterocyclic analogs of nicotinic acid, with which it is isosteric. Pyrazinamide has recently been elevated to first-line status in short-term tuberculosis treatment regimens because of its tuberculocidal activity and comparatively low short-term toxicity. Since pyrazinamide is not active against metabolically inactive tubercle bacilli, it is not considered suitable for long-term therapy. Potential hepatotoxicity also obviates long-term use of the drug. Pyrazinamide is maximally effective in the low pH environment that exists in macrophages (monocytes). Evidence suggests bioactivation of pyrazinamide to pyrazinoic acid by an amidase present in mycobacteria.
- Pyrazinamide
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- US $1.00 / KG
- 2021-09-29
- CAS:98-96-4
- Min. Order: 1KG
- Purity: 99%~101.0% ,BP2015
- Supply Ability: 5ton/month
- Pyrazinamide USP/EP/BP
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- US $1.10 / g
- 2021-07-17
- CAS:98-96-4
- Min. Order: 1g
- Purity: 99.9%
- Supply Ability: 100 Tons Min
- Pyrazinamide
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- US $15.00-10.00 / KG
- 2021-07-13
- CAS:98-96-4
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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98-96-4
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