| | 90779-69-4 Basic information More.. |
| Product Name: | Atosiban | | Synonyms: | 1-deamino-2d-tyr-(oet)-4-thr-8-orn-oxytocin;oxytocin,1-(3-mercaptopropanoicacid)-2-(o-ethyl-d-tyrosine)-4-l-threonine-8-l;rwj22164;1-(3-Mercaptopropionic acid)-2-(3-(p-ethoxyphenyl)-D-alanine)-4-L-thre onine-8-L-ornithineoxytocin;[Mpr-D-Tyr(OEt)-Ile-Thr-Asn-Cys]-Pro-Orn-Gly-NH2;(2S)-N-[(1S)-4-Amino-1-(carbamoylmethylcarbamoyl)butyl]-1-[(4S,7S,13S,16R)-13-[(2S)-butan-2-yl]-7-(carbamoylmethyl)-16-[(4-ethoxyphenyl)methyl]-10-(1-hydroxyethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide;1-(3-Mercaptopropanoic acid)-2-(O-ethyl-D-tyrosine)-4-L-threonine-8-L-ornithineoxytocin;1-Deamino-2-D-Tyr-(O-ethyl)-4-Thr-8-ornoxytocin | | CAS: | 90779-69-4 | | MF: | C43H67N11O12S2 | | MW: | 994.19 | | EINECS: | 806-815-5 | | Mol File: | 90779-69-4.mol |  |
Use
Atosiban was introduced in the UK as an injectable inhibitor of preterm labor, a major
cause of infant morbidity and mortality. This peptidic oxytocin analog is an antagonist of
the vasopressin V1a receptor and of the oxytocin receptor which is found in dramatically
increased concentration in the uterine myometrium of pregnant women near term. It
competitively inhibited contractions in the pregnant guinea pig uterus induced by oxytocin
and vasopressin. In a multicenter, double-blind, placebo-controlled trial, treatment with
atosiban caused pregnancy prolongation for up to 7 days in women with more than 28
weeks of gestation. In a comparative clinical trial, atosiban showed a comparable tocolytic
action (uterine relaxant) to ritodrine but the former was significantly better tolerated,
especially with regards to maternal cardiovascular side effects. In healthy volunteers,
plasma levels of atosiban decreased bi-exponentially with an initial and a terminal half-life of 21 min and 1.7h respectively.
- Atosiban
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- US $10.00 / kg
- 2024-03-26
- CAS:90779-69-4
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 1000kg
- Atosiban
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- US $120.00 / kg
- 2024-01-18
- CAS:90779-69-4
- Min. Order: 45436kg
- Purity: 99%
- Supply Ability: 435
- Atosiban
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- US $80.00-800.00 / kg
- 2024-01-02
- CAS:90779-69-4
- Min. Order: 10kg
- Purity: 0.99
- Supply Ability: 20tons
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90779-69-4
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