1404-93-9 Basic information More..
Product Name:Vancomycin hydrochloride
Synonyms:VANCOMYCIN HCL;VANCOMYCIN HCL, STREPTOMYCES ORIENTALIS;VANCOMYCIN HYDROCHLORIDE;Vancomycin monohydrochloride tetrahydrate;Vanconycin monodrochloride tetrahydrate;VANCOMYCIN HYDROCHLORIDE FROM STREPTO-MY CES ORIENTALIS;VANCOMYCIN HYDROCHLORIDE PLANT CELL*CULT URE TESTED;VANCOMYCIN HYDROCHLORIDE, BIOTECHNOLOGY
CAS:1404-93-9
MF:C66H76Cl3N9O24
MW:1485.71
EINECS:604-193-8
Mol File:1404-93-9.mol
1404-93-9

Use

1. this drug has a strong irritation effect on the tissue is not suitable for intramuscular or intravenous injection; intravenous infusion should try to avoid liquid leakage. 2. In order to reduce the incidence of adverse reactions (such as "red neck syndrome", thrombophlebitis), the intravenous infusion rate should not be too fast with each infusion time beinng at least 1 hour or more. 3. for the treatment of staphylococcal endocarditis, the treatment period should be not less than 28 days. 4. vancomycin hydrochloride is incompatible for being used in combination with chloramphenicol, heparin, aminophylline, sodium bicarbonate, steroid hormones, methicillin, medicines containing heavy metals, and other alkaline solution. 5. overdose treatment: excessive administration of vancomycin hydrochloride can cause oliguria and renal failure. Treatment process comprising: (1) symptomatic and supportive treatment. (2) Conventional hemodialysis and peritoneal dialysis is ineffective in clearing the drugs; but blood perfusion or blood filtration can increase the drug clearance rate. 6. preparation of the solution: (1) Preparation of oral solution: every bottle containing 500 mg of vancomycin should be diluted with distilled water to prepare 500mg/6ml solution for oral administration, the oral solution can be stored for 14 days at 4 °C refrigerator. (2) Preparation of intravenous fluid infusion: ① intermittent infusion, the solution is prepared with 500mg drugs and 10 ml water, and then add it to a 5% glucose injection or 0.9% sodium chloride injection for dilution to less than 5mg/ml before the infusion. The infusion time of a dose of 500mg should be at least 60 minutes and should be at least 100 minutes for a dose of 1000 mg. For patients who is necessary to subject to restricted liquid amount, the highest concentrations can be up to 10mg/ml. ② Upon continuous intravenous infusion, 1~2g dose needs to be added to a sufficient amount of 5% glucose injection or 0.9% sodium chloride injection. 7. the maintenance dose for patients of renal dysfunction can be calculated as follows: the maintenance dose (md/d) = 150 + (15 × creatinine clearance rate of the patient ml/min). 8. plasma concentration should be monitored during treatment; the peak concentration should not exceed 25~40μg/ml, trough concentration should not exceed 5~10μg/ml. Concentration higher than 60μg/ml is within the range of poisoning. If you can’t monitor the blood concentration, adjust the dose according to the creatinine clearance rate.

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