606143-52-6 Basic information More..
Product Name:Selumetinib
Synonyms:ARRY 142886;AZD 6244;Selumetinib AZD624;5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-car;Selumetinib;5-(4-Bromo-2-chlorophenylamino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzo[d]imidazole-6-carboxamide;6-(4-Bromo-2-chlorophenylamino)-7-fluoro-N-(2-hydroxyethoxy)-3-methyl-3H-benzo[d]imidazole-5-carboxamide;SeluMatinib(5-[(4-BroMo-2-chlorophenyl)aMino]-4-fluoro-N-(2-hydroxyethoxy)-1-Methyl-1H-benziMidazole-6-carboxaMide
CAS:606143-52-6
MF:C17H15BrClFN4O3
MW:457.68
EINECS:207-313-3
Mol File:606143-52-6.mol
606143-52-6

Use

In phase II clinical trials of radioiodine-refractory papillary thyroid carcinoma, 39 patients took daily oral doses of Selumetinib (100mg bid) for 28 days; results showed that 21 patients conditions stabilized (54%), 11 patients conditions worsened (28%), 49% patients conditions were stable for 16 weeks, 36% patients conditions were stable for 24 weeks, and survival terms did not progress to 32 weeks. Negative reactions mainly consisted of rashes (59%), diarrhea (44%), and weakness (41%). Some studies found that after treating 20 patients with thyroid cancer with Selumetinib (75mg bid) for 4 weeks, Selumetinib increased the iodine uptake and retention of patients with radioiodine-refractory papillary thyroid carcinoma. In a blind and random comparative study between a Selumetinib and Docetaxel (DOC) combination treatment group and DOC and placebo treatment group for 87 mutant NSCLSC patients, survival times were 9.4 months and 5.2 months, PFS were 5.3 months and 2.1 months, RR were 37% and 0%, thus showing dramatic differences. Selumetinibs main negative reactions include neutrophil depletion, dermatitis, and respiratory failure.

Selumetinib manufacturers

  • Selumetinib
  • US $10.00 / kg
  • 2022-04-22
  • CAS:606143-52-6
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 10tons
  • SeluMetinib
  • US $0.00 / gram
  • 2022-02-18
  • CAS:606143-52-6
  • Min. Order: 1gram
  • Purity: 99%
  • Supply Ability: 10kg
  • Selumetinib USP/EP/BP
  • US $1.10 / g
  • 2021-08-18
  • CAS:606143-52-6
  • Min. Order: 1g
  • Purity: 99.9%
  • Supply Ability: 100 Tons min
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