| | 86-42-0 Basic information More.. |
| Product Name: | Amodiaquine | | Synonyms: | 4-((7-chloro-4-quinolyl)amino)-alpha-(diethylamino)-o-creso;4-((7-Chloro-4-quinolyl)amino)-alpha-(diethylamino)-o-cresol;4-[(7-Chloro-4-quinolinyl)amino]-alpha-(diethylamino)-o-cresol;7-Chloro-4-(3-diethylaminomethyl-4-hydroxyphenylamino)quinoline;Amodiaquine, ring-closed;CAM-AQ1;CAM-AQI;Camochin | | CAS: | 86-42-0 | | MF: | C20H22ClN3O | | MW: | 355.86 | | EINECS: | 201-669-3 | | Mol File: | 86-42-0.mol |  |
Use
Amodiaquine, an antimalarial agent related to chloroquine, was
introduced over 40 years ago for the treatment and prophylaxis of malaria. The
drug was voluntarily withdrawn in the United Kingdom in 1975 for commercial
reasons but was subsequently reintroduced in 1985 to meet the medical demand
for an antimalarial drug to deal with the rapid spread of chloroquine-resistant
falciparum malaria in Asia and Africa. By 1986 a significant number of cases of
agranulocytosis associated with prophylactic use, some of which were fatal, had
been reported there and it has been estimated that the frequency of this risk is of
the order of 1:2,000. Although most cases occurred when amodiaquine had been
used in combination with other antimalarials, the major manufacturer decided to
withdraw the prophylactic indication worldwide following discussions with experts.
Preparations remain available for the treatment of acute attacks of malaria which
involves only a short period of exposure to the drug.
(Reference: (WHODI) WHO Drug Information, 1, 5, 1987)
- Amodiaquine USP/EP/BP
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- US $1.10 / g
- 2021-06-18
- CAS:86-42-0
- Min. Order: 1g
- Purity: 99.9%
- Supply Ability: 100 Tons Min
- Amodiaquine
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- US $1.00 / KG
- 2020-02-06
- CAS:86-42-0
- Min. Order: 1KG
- Purity: Min98% HPLC
- Supply Ability: g/kg/ton
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86-42-0
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