179324-69-7 Basic information More..
Product Name:Bortezomib
Synonyms:Bortezomib for Injection;3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butylboronic acid;Boronic acid, B-[(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)aMino]propyl]aMino]bu;MG-341 PS-341;BortezoMib Base;BortezoMib-D8;bortezoMib(other);MLM341
CAS:179324-69-7
MF:C19H25BN4O4
MW:384.24
EINECS:605-854-3
Mol File:179324-69-7.mol
179324-69-7

Use

Bortezomib belong to the class of drugs called proteasome inhibitors and is licensed in the United States and the United Kingdom for the treatment of multiple myeloma. The drug has been licensed for patients in whom the myeloma has progressed despite prior treatment or where a bone marrow transplant is not possible or was not successful. It is marketed under the name Velcade? or Cytomib?. Velcade is administered via injection and is sold as powder for reconstitution. Bortezomib was the first drug approved in the new drug class of proteasome inhibitors and boron seems to be its active element. For the mode of action, it is believed that the boron atom binds with high affinity and specificity to the catalytic site of 26S proteasome and inhibits its action. Therapy with Bortezomib can lead to a variety of adverse reactions, including peripheral neuropathy, myelosuppression, renal impairment and gastrointestinal (GI) disturbances together with changes in taste. Nevertheless, the side effects are in most cases less severe than with alternative treatment options such as bone marrow transplantation.

Lastest Price from Bortezomib manufacturers

  • Bortezomib
  • US $0.00 / Kg/Bag
  • 2019-09-02
  • CAS:179324-69-7
  • Min. Order: 10g
  • Purity: 99%
  • Supply Ability: 800 kg
  • Bortezomib
  • US $0.00-0.00 / KG
  • 2019-08-16
  • CAS:179324-69-7
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 10kg/month
  • Bortezomib
  • US $10.00 / KG
  • 2019-08-07
  • CAS:179324-69-7
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 10 mt
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